Enhancement of Simvastatin ex vivo Permeation from Mucoadhesive Buccal Films Loaded with Dual Drug Release Carriers

BACKGROUND: Simvastatin (SMV), a hypocholesterolemic agent, suffers from very low bioavailability due to its poor aqueous solubility and extensive first-pass metabolism. METHODS: Two SMV carrier systems, namely, polymeric drug inclusion complex (IC) and mixed micelles (MM) nanoparticles, were develo...

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Detalles Bibliográficos
Autores principales: Ahmed, Tarek A, Bawazir, Alaa O, Alharbi, Waleed S, Safo, Martin K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294046/
https://www.ncbi.nlm.nih.gov/pubmed/32606661
http://dx.doi.org/10.2147/IJN.S256925

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