Combination BET Family Protein and HDAC Inhibition Synergistically Elicits Chondrosarcoma Cell Apoptosis Through RAD51-Related DNA Damage Repair

BACKGROUND: Chondrosarcoma is the second-most common type of bone tumor and has inherent resistance to conventional chemotherapy. Present study aimed to explore the therapeutic effect and specific mechanism(s) of combination BET family protein and HDAC inhibition in chondrosarcoma. METHODS: Two chon...

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Detalles Bibliográficos
Autores principales: Huan, Songwei, Gui, Tao, Xu, Qiutong, Zhuang, Songkuan, Li, Zhenyan, Shi, Yuling, Lin, Jiebin, Gong, Bin, Miao, Guiqiang, Tam, Manseng, Zhang, Huan-Tian, Zha, Zhengang, Wu, Chunfei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294047/
https://www.ncbi.nlm.nih.gov/pubmed/32606937
http://dx.doi.org/10.2147/CMAR.S254412

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