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(19)F NMR reveals the conformational properties of free thrombin and its zymogen precursor prethrombin-2

The conformational properties of trypsin-like proteases and their zymogen forms remain controversial because of a lack of sufficient information on their free forms. Specifically, it is unclear whether the free protease is zymogen-like and shifts to its mature form upon a ligand-induced fit or exist...

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Detalles Bibliográficos
Autores principales:	Ruben, Eliza A., Gandhi, Prafull S., Chen, Zhiwei, Koester, Sarah K., DeKoster, Gregory T., Frieden, Carl, Di Cera, Enrico
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Enzymology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294081/ https://www.ncbi.nlm.nih.gov/pubmed/32358061 http://dx.doi.org/10.1074/jbc.RA120.013419

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