Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6), efficiently inhibits amyloid aggregation. This inhibition depends on a unique motif with conserved serine and threonine (S/T) residues that have a high capacity for hydrogen bonding. Global analysis of ki...

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Detalles Bibliográficos
Autores principales: Österlund, Nicklas, Lundqvist, Martin, Ilag, Leopold L., Gräslund, Astrid, Emanuelsson, Cecilia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2020
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294096/
https://www.ncbi.nlm.nih.gov/pubmed/32350108
http://dx.doi.org/10.1074/jbc.RA120.013459

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294096/
https://www.ncbi.nlm.nih.gov/pubmed/32350108
http://dx.doi.org/10.1074/jbc.RA120.013459

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