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Amyloid-β oligomers are captured by the DNAJB6 chaperone: Direct detection of interactions that can prevent primary nucleation

A human molecular chaperone protein, DnaJ heat shock protein family (Hsp40) member B6 (DNAJB6), efficiently inhibits amyloid aggregation. This inhibition depends on a unique motif with conserved serine and threonine (S/T) residues that have a high capacity for hydrogen bonding. Global analysis of ki...

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Detalles Bibliográficos
Autores principales:	Österlund, Nicklas, Lundqvist, Martin, Ilag, Leopold L., Gräslund, Astrid, Emanuelsson, Cecilia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2020
Materias:	Editors' Picks
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294096/ https://www.ncbi.nlm.nih.gov/pubmed/32350108 http://dx.doi.org/10.1074/jbc.RA120.013459

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