E‐cadherin deregulation in breast cancer

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe th...

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Detalles Bibliográficos
Autores principales: Corso, Giovanni, Figueiredo, Joana, De Angelis, Simone Pietro, Corso, Federica, Girardi, Antonia, Pereira, Joana, Seruca, Raquel, Bonanni, Bernardo, Carneiro, Patricia, Pravettoni, Gabriella, Guerini Rocco, Elena, Veronesi, Paolo, Montagna, Giacomo, Sacchini, Virgilio, Gandini, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294130/
https://www.ncbi.nlm.nih.gov/pubmed/32301282
http://dx.doi.org/10.1111/jcmm.15140
Descripción
Sumario:E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.

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