E‐cadherin deregulation in breast cancer

E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe th...

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Detalles Bibliográficos
Autores principales: Corso, Giovanni, Figueiredo, Joana, De Angelis, Simone Pietro, Corso, Federica, Girardi, Antonia, Pereira, Joana, Seruca, Raquel, Bonanni, Bernardo, Carneiro, Patricia, Pravettoni, Gabriella, Guerini Rocco, Elena, Veronesi, Paolo, Montagna, Giacomo, Sacchini, Virgilio, Gandini, Sara
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Reviews
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294130/
https://www.ncbi.nlm.nih.gov/pubmed/32301282
http://dx.doi.org/10.1111/jcmm.15140
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author Corso, Giovanni
Figueiredo, Joana
De Angelis, Simone Pietro
Corso, Federica
Girardi, Antonia
Pereira, Joana
Seruca, Raquel
Bonanni, Bernardo
Carneiro, Patricia
Pravettoni, Gabriella
Guerini Rocco, Elena
Veronesi, Paolo
Montagna, Giacomo
Sacchini, Virgilio
Gandini, Sara
author_facet Corso, Giovanni
Figueiredo, Joana
De Angelis, Simone Pietro
Corso, Federica
Girardi, Antonia
Pereira, Joana
Seruca, Raquel
Bonanni, Bernardo
Carneiro, Patricia
Pravettoni, Gabriella
Guerini Rocco, Elena
Veronesi, Paolo
Montagna, Giacomo
Sacchini, Virgilio
Gandini, Sara
author_sort Corso, Giovanni
collection PubMed
description E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy.
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spelling pubmed-72941302020-06-15 E‐cadherin deregulation in breast cancer Corso, Giovanni Figueiredo, Joana De Angelis, Simone Pietro Corso, Federica Girardi, Antonia Pereira, Joana Seruca, Raquel Bonanni, Bernardo Carneiro, Patricia Pravettoni, Gabriella Guerini Rocco, Elena Veronesi, Paolo Montagna, Giacomo Sacchini, Virgilio Gandini, Sara J Cell Mol Med Reviews E‐cadherin protein (CDH1 gene) integrity is fundamental to the process of epithelial polarization and differentiation. Deregulation of the E‐cadherin function plays a crucial role in breast cancer metastases, with worse prognosis and shorter overall survival. In this narrative review, we describe the inactivating mechanisms underlying CDH1 gene activity and its possible translation to clinical practice as a prognostic biomarker and as a potential targeted therapy. John Wiley and Sons Inc. 2020-04-16 2020-06 /pmc/articles/PMC7294130/ /pubmed/32301282 http://dx.doi.org/10.1111/jcmm.15140 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Corso, Giovanni
Figueiredo, Joana
De Angelis, Simone Pietro
Corso, Federica
Girardi, Antonia
Pereira, Joana
Seruca, Raquel
Bonanni, Bernardo
Carneiro, Patricia
Pravettoni, Gabriella
Guerini Rocco, Elena
Veronesi, Paolo
Montagna, Giacomo
Sacchini, Virgilio
Gandini, Sara
E‐cadherin deregulation in breast cancer
title E‐cadherin deregulation in breast cancer
title_full E‐cadherin deregulation in breast cancer
title_fullStr E‐cadherin deregulation in breast cancer
title_full_unstemmed E‐cadherin deregulation in breast cancer
title_short E‐cadherin deregulation in breast cancer
title_sort e‐cadherin deregulation in breast cancer
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294130/
https://www.ncbi.nlm.nih.gov/pubmed/32301282
http://dx.doi.org/10.1111/jcmm.15140
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