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The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk

Studies examining the associations between the interleukin‐6 (IL‐6) rs1800795 and rs1800796 gene polymorphisms and risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate the accurately determine role of these two polymorphisms in CAD risk. PubMed, Embase, VIP, Wan fang a...

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Autores principales: Lu, Shuai, Wang, Ya, Wang, Yijun, Hu, Jing, Di, Wu, Liu, Shuangye, Zeng, Xiaohui, Yu, Guo, Wang, Yan, Wang, Zhaohui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294134/
https://www.ncbi.nlm.nih.gov/pubmed/32374489
http://dx.doi.org/10.1111/jcmm.15246
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author Lu, Shuai
Wang, Ya
Wang, Yijun
Hu, Jing
Di, Wu
Liu, Shuangye
Zeng, Xiaohui
Yu, Guo
Wang, Yan
Wang, Zhaohui
author_facet Lu, Shuai
Wang, Ya
Wang, Yijun
Hu, Jing
Di, Wu
Liu, Shuangye
Zeng, Xiaohui
Yu, Guo
Wang, Yan
Wang, Zhaohui
author_sort Lu, Shuai
collection PubMed
description Studies examining the associations between the interleukin‐6 (IL‐6) rs1800795 and rs1800796 gene polymorphisms and risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate the accurately determine role of these two polymorphisms in CAD risk. PubMed, Embase, VIP, Wan fang and China National Knowledge Infrastructure databases were searched. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The trial sequential analysis (TSA) was conducted, and bioinformatics tools were employed. A total of thirty‐seven articles were obtained. For the IL‐6 rs1800795 polymorphism, 9411 CAD patients and 3161 controls were included, 4720 patients with CAD, and 5000 controls were included for the IL‐6 rs1800796 polymorphism. In the pooled analysis, significant associations were only observed for the rs1800796 polymorphism (allelic: OR [95%CI] = 1.28 [1.13, 1.44], dominant: OR [95%CI] = 1.35 [1.17, 1.57], recessive: OR [95%CI] = 1.35 [1.18, 1.55], heterozygote: OR [95%CI] = 1.26 [1.15, 1.37], homozygote: OR [95%CI] = 1.62 [1.23, 2.13]). Significant associations were detected in the Asian and Mongoloid populations and ‘more than 500’ subgroup for the rs1800795 polymorphism. TSA confirmed the true‐positive results for the rs1800796 polymorphism. The bioinformatics analysis showed that the two polymorphisms played important roles in the gene transcription. The IL‐6 rs1800796 polymorphism is associated with an increased susceptibility to CAD and is a risk factor for CAD. The IL‐6 rs1800795 polymorphism is associated with an increased risk of CAD in Asians, particularly in Chinese, and a decreased risk of CAD in an African population is remarkably observed.
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spelling pubmed-72941342020-06-15 The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk Lu, Shuai Wang, Ya Wang, Yijun Hu, Jing Di, Wu Liu, Shuangye Zeng, Xiaohui Yu, Guo Wang, Yan Wang, Zhaohui J Cell Mol Med Original Articles Studies examining the associations between the interleukin‐6 (IL‐6) rs1800795 and rs1800796 gene polymorphisms and risk of coronary artery disease (CAD) remain controversial. Our aim was to evaluate the accurately determine role of these two polymorphisms in CAD risk. PubMed, Embase, VIP, Wan fang and China National Knowledge Infrastructure databases were searched. The odds ratios (ORs) and 95% confidence intervals (CIs) were calculated. The trial sequential analysis (TSA) was conducted, and bioinformatics tools were employed. A total of thirty‐seven articles were obtained. For the IL‐6 rs1800795 polymorphism, 9411 CAD patients and 3161 controls were included, 4720 patients with CAD, and 5000 controls were included for the IL‐6 rs1800796 polymorphism. In the pooled analysis, significant associations were only observed for the rs1800796 polymorphism (allelic: OR [95%CI] = 1.28 [1.13, 1.44], dominant: OR [95%CI] = 1.35 [1.17, 1.57], recessive: OR [95%CI] = 1.35 [1.18, 1.55], heterozygote: OR [95%CI] = 1.26 [1.15, 1.37], homozygote: OR [95%CI] = 1.62 [1.23, 2.13]). Significant associations were detected in the Asian and Mongoloid populations and ‘more than 500’ subgroup for the rs1800795 polymorphism. TSA confirmed the true‐positive results for the rs1800796 polymorphism. The bioinformatics analysis showed that the two polymorphisms played important roles in the gene transcription. The IL‐6 rs1800796 polymorphism is associated with an increased susceptibility to CAD and is a risk factor for CAD. The IL‐6 rs1800795 polymorphism is associated with an increased risk of CAD in Asians, particularly in Chinese, and a decreased risk of CAD in an African population is remarkably observed. John Wiley and Sons Inc. 2020-05-06 2020-06 /pmc/articles/PMC7294134/ /pubmed/32374489 http://dx.doi.org/10.1111/jcmm.15246 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine andJohn Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Articles
Lu, Shuai
Wang, Ya
Wang, Yijun
Hu, Jing
Di, Wu
Liu, Shuangye
Zeng, Xiaohui
Yu, Guo
Wang, Yan
Wang, Zhaohui
The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title_full The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title_fullStr The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title_full_unstemmed The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title_short The IL-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
title_sort il-6 rs1800795 and rs1800796 polymorphisms are associated with coronary artery disease risk
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294134/
https://www.ncbi.nlm.nih.gov/pubmed/32374489
http://dx.doi.org/10.1111/jcmm.15246
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