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Extracellular S100A4 as a key player in fibrotic diseases

Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction. Considerable evidence now indicates that inflammation plays a critical role in the initiation and progression of...

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Autores principales: Li, Zhenzhen, Li, Yanan, Liu, Shuangqing, Qin, Zhihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294136/
https://www.ncbi.nlm.nih.gov/pubmed/32307910
http://dx.doi.org/10.1111/jcmm.15259
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author Li, Zhenzhen
Li, Yanan
Liu, Shuangqing
Qin, Zhihai
author_facet Li, Zhenzhen
Li, Yanan
Liu, Shuangqing
Qin, Zhihai
author_sort Li, Zhenzhen
collection PubMed
description Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction. Considerable evidence now indicates that inflammation plays a critical role in the initiation and progression of organ fibrosis. S100A4 protein, a ubiquitous member of the S100 family, has recently been discovered as a potential factor implicated in fibrotic diseases. S100A4 protein is released at inflammatory site and has a certain biological function to promote cell motility, invasion, ECM remodelling, autophagy and angiogenesis. In addition, extracellular S100A4 is also a potential causation of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions. Elevated S100A4 level in patients’ serum closely correlates with disease activity in several fibrotic diseases and serves as a useful biomarker for diagnosis and monitoring disease progression. Analyses of knockout mouse models have identified a functional role of extracellular S100A4 protein in fibrotic diseases, suggesting that suppressing its expression, release or function might be a promising therapeutic strategy. This review will focus on the role of extracellular S100A4 as a key regulator of pro‐inflammatory signalling pathways and its relative biological processes involved in the pathogenesis of fibrosis.
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spelling pubmed-72941362020-06-15 Extracellular S100A4 as a key player in fibrotic diseases Li, Zhenzhen Li, Yanan Liu, Shuangqing Qin, Zhihai J Cell Mol Med Reviews Fibrosis is characterized by fibroblast activation, extracellular matrix (ECM) accumulation and infiltration of inflammatory cells that sometimes leads to irreversible organ dysfunction. Considerable evidence now indicates that inflammation plays a critical role in the initiation and progression of organ fibrosis. S100A4 protein, a ubiquitous member of the S100 family, has recently been discovered as a potential factor implicated in fibrotic diseases. S100A4 protein is released at inflammatory site and has a certain biological function to promote cell motility, invasion, ECM remodelling, autophagy and angiogenesis. In addition, extracellular S100A4 is also a potential causation of inflammatory processes and induces the release of cytokines and growth factors under different pathological conditions. Elevated S100A4 level in patients’ serum closely correlates with disease activity in several fibrotic diseases and serves as a useful biomarker for diagnosis and monitoring disease progression. Analyses of knockout mouse models have identified a functional role of extracellular S100A4 protein in fibrotic diseases, suggesting that suppressing its expression, release or function might be a promising therapeutic strategy. This review will focus on the role of extracellular S100A4 as a key regulator of pro‐inflammatory signalling pathways and its relative biological processes involved in the pathogenesis of fibrosis. John Wiley and Sons Inc. 2020-04-19 2020-06 /pmc/articles/PMC7294136/ /pubmed/32307910 http://dx.doi.org/10.1111/jcmm.15259 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by Foundation for Cellular and Molecular Medicine and John Wiley & Sons Ltd. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Reviews
Li, Zhenzhen
Li, Yanan
Liu, Shuangqing
Qin, Zhihai
Extracellular S100A4 as a key player in fibrotic diseases
title Extracellular S100A4 as a key player in fibrotic diseases
title_full Extracellular S100A4 as a key player in fibrotic diseases
title_fullStr Extracellular S100A4 as a key player in fibrotic diseases
title_full_unstemmed Extracellular S100A4 as a key player in fibrotic diseases
title_short Extracellular S100A4 as a key player in fibrotic diseases
title_sort extracellular s100a4 as a key player in fibrotic diseases
topic Reviews
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294136/
https://www.ncbi.nlm.nih.gov/pubmed/32307910
http://dx.doi.org/10.1111/jcmm.15259
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