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Dysregulation of NIPBL leads to impaired RUNX1 expression and haematopoietic defects

The transcription factor RUNX1, a pivotal regulator of HSCs and haematopoiesis, is a frequent target of chromosomal translocations, point mutations or altered gene/protein dosage. These modifications lead or contribute to the development of myelodysplasia, leukaemia or platelet disorders. A better u...

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Detalles Bibliográficos
Autores principales:	Mazzola, Mara, Pezzotta, Alex, Fazio, Grazia, Rigamonti, Alessandra, Bresciani, Erica, Gaudenzi, Germano, Pelleri, Maria Chiara, Saitta, Claudia, Ferrari, Luca, Parma, Matteo, Fumagalli, Monica, Biondi, Andrea, Cazzaniga, Giovanni, Marozzi, Anna, Pistocchi, Anna
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294146/ https://www.ncbi.nlm.nih.gov/pubmed/32323916 http://dx.doi.org/10.1111/jcmm.15269

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