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High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study
To test the hypothesis that an impaired mitochondrial function is associated with altered central venous oxygen saturation (ScvO(2)), venous‐to‐arterial carbon dioxide tension difference (delta PCO(2)) or serum lactate in sepsis patients. This prospective cohort study was conducted in a single terti...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294163/ https://www.ncbi.nlm.nih.gov/pubmed/32352229 http://dx.doi.org/10.1111/jcmm.15299 |
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author | Wittayachamnankul, Borwon Apaijai, Nattayaporn Sutham, Krongkarn Chenthanakij, Boriboon Liwsrisakun, Chalerm Jaiwongkam, Thidarat Chattipakorn, Siriporn C. Chattipakorn, Nipon |
author_facet | Wittayachamnankul, Borwon Apaijai, Nattayaporn Sutham, Krongkarn Chenthanakij, Boriboon Liwsrisakun, Chalerm Jaiwongkam, Thidarat Chattipakorn, Siriporn C. Chattipakorn, Nipon |
author_sort | Wittayachamnankul, Borwon |
collection | PubMed |
description | To test the hypothesis that an impaired mitochondrial function is associated with altered central venous oxygen saturation (ScvO(2)), venous‐to‐arterial carbon dioxide tension difference (delta PCO(2)) or serum lactate in sepsis patients. This prospective cohort study was conducted in a single tertiary emergency department between April 2017 and March 2019. Patients with suspected sepsis were included in the study. Serum lactate was obtained in sepsis, ScvO(2) and delta PCO(2) were evaluated in septic shock patients. Mitochondrial function was determined from the peripheral blood mononuclear cells. Forty‐six patients with suspected sepsis were included. Of these, twenty patients were septic shock. Mitochondrial oxidative stress levels were increased in the high ScvO(2) group (ScvO(2) > 80%, n = 6), compared with the normal (70%‐80%, n = 9) and low ScvO(2) (<70%, n = 5) groups. A strong linear relationship was observed between the mitochondrial oxidative stress and ScvO(2) (r = .75; P = .01). However, mitochondrial respiration was increased in the low ScvO(2) group. In addition, mitochondrial complex II protein levels were significantly decreased in the high ScvO(2) group (P < .05). Additionally, there was no correlation between serum lactate, delta PCO(2), and mitochondria oxidative stress or mitochondria function. ScvO(2) can be potentially useful for developing new therapeutics to reduce mitochondrial dysfunction in septic shock patient. |
format | Online Article Text |
id | pubmed-7294163 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72941632020-06-15 High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study Wittayachamnankul, Borwon Apaijai, Nattayaporn Sutham, Krongkarn Chenthanakij, Boriboon Liwsrisakun, Chalerm Jaiwongkam, Thidarat Chattipakorn, Siriporn C. Chattipakorn, Nipon J Cell Mol Med Original Articles To test the hypothesis that an impaired mitochondrial function is associated with altered central venous oxygen saturation (ScvO(2)), venous‐to‐arterial carbon dioxide tension difference (delta PCO(2)) or serum lactate in sepsis patients. This prospective cohort study was conducted in a single tertiary emergency department between April 2017 and March 2019. Patients with suspected sepsis were included in the study. Serum lactate was obtained in sepsis, ScvO(2) and delta PCO(2) were evaluated in septic shock patients. Mitochondrial function was determined from the peripheral blood mononuclear cells. Forty‐six patients with suspected sepsis were included. Of these, twenty patients were septic shock. Mitochondrial oxidative stress levels were increased in the high ScvO(2) group (ScvO(2) > 80%, n = 6), compared with the normal (70%‐80%, n = 9) and low ScvO(2) (<70%, n = 5) groups. A strong linear relationship was observed between the mitochondrial oxidative stress and ScvO(2) (r = .75; P = .01). However, mitochondrial respiration was increased in the low ScvO(2) group. In addition, mitochondrial complex II protein levels were significantly decreased in the high ScvO(2) group (P < .05). Additionally, there was no correlation between serum lactate, delta PCO(2), and mitochondria oxidative stress or mitochondria function. ScvO(2) can be potentially useful for developing new therapeutics to reduce mitochondrial dysfunction in septic shock patient. John Wiley and Sons Inc. 2020-04-30 2020-06 /pmc/articles/PMC7294163/ /pubmed/32352229 http://dx.doi.org/10.1111/jcmm.15299 Text en © 2020 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Articles Wittayachamnankul, Borwon Apaijai, Nattayaporn Sutham, Krongkarn Chenthanakij, Boriboon Liwsrisakun, Chalerm Jaiwongkam, Thidarat Chattipakorn, Siriporn C. Chattipakorn, Nipon High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title | High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title_full | High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title_fullStr | High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title_full_unstemmed | High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title_short | High central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: A prospective observational study |
title_sort | high central venous oxygen saturation is associated with mitochondrial dysfunction in septic shock: a prospective observational study |
topic | Original Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294163/ https://www.ncbi.nlm.nih.gov/pubmed/32352229 http://dx.doi.org/10.1111/jcmm.15299 |
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