Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells

Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuro-immune units that occupy distinct anatomical niches within the gut. Here we will review the recent advances in our understanding of neuro-immune crosstalk within the gut, wit...

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Detalles Bibliográficos
Autores principales: Stakenborg, Nathalie, Viola, Maria F., Boeckxstaens, Guy E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Current Biology 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294228/
https://www.ncbi.nlm.nih.gov/pubmed/31862627
http://dx.doi.org/10.1016/j.conb.2019.11.020
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author Stakenborg, Nathalie
Viola, Maria F.
Boeckxstaens, Guy E.
author_facet Stakenborg, Nathalie
Viola, Maria F.
Boeckxstaens, Guy E.
author_sort Stakenborg, Nathalie
collection PubMed
description Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuro-immune units that occupy distinct anatomical niches within the gut. Here we will review the recent advances in our understanding of neuro-immune crosstalk within the gut, with focus on macrophages, mast cells and innate lymphoid cells. In particular, we will discuss the role of neuron-immune cell crosstalk in homeostasis, and how aberrant communication may underlie disease in the gastro-intestinal tract.
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spelling pubmed-72942282020-06-17 Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells Stakenborg, Nathalie Viola, Maria F. Boeckxstaens, Guy E. Curr Opin Neurobiol Article Intestinal homeostasis relies on the reciprocal crosstalk between enteric neurons and immune cells, which together form neuro-immune units that occupy distinct anatomical niches within the gut. Here we will review the recent advances in our understanding of neuro-immune crosstalk within the gut, with focus on macrophages, mast cells and innate lymphoid cells. In particular, we will discuss the role of neuron-immune cell crosstalk in homeostasis, and how aberrant communication may underlie disease in the gastro-intestinal tract. Current Biology 2020-06 /pmc/articles/PMC7294228/ /pubmed/31862627 http://dx.doi.org/10.1016/j.conb.2019.11.020 Text en © 2019 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Stakenborg, Nathalie
Viola, Maria F.
Boeckxstaens, Guy E.
Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title_full Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title_fullStr Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title_full_unstemmed Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title_short Intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
title_sort intestinal neuro-immune interactions: focus on macrophages, mast cells and innate lymphoid cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294228/
https://www.ncbi.nlm.nih.gov/pubmed/31862627
http://dx.doi.org/10.1016/j.conb.2019.11.020
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