Hydrostatic pressure regulates CYP1A2 expression in human hepatocytes via a mechanosensitive aryl hydrocarbon receptor-dependent pathway

Approximately 75% of xenobiotics are primarily eliminated through metabolism; thus the accurate scaling of metabolic clearance is vital to successful drug development. Yet, when data is scaled from in vitro to in vivo, hepatic metabolic clearance, the primary source of metabolism, is still commonly...

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Detalles Bibliográficos
Autores principales: Burton, Lewis, Scaife, Paula, Paine, Stuart W., Mellor, Howard R., Abernethy, Lynn, Littlewood, Peter, Rauch, Cyril
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Physiological Society 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294326/
https://www.ncbi.nlm.nih.gov/pubmed/32159360
http://dx.doi.org/10.1152/ajpcell.00472.2019

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