Cargando…

Early Restoration of Shank3 Expression in Shank3 Knock-Out Mice Prevents Core ASD-Like Behavioral Phenotypes

Several genes are associated with increased risk for autism spectrum disorder (ASD), neurodevelopmental disorders that present with repetitive movements and restricted interests along with deficits in social interaction/communication. While genetic alterations associated with ASD are present early i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jaramillo, Thomas C., Xuan, Zhong, Reimers, Jeremy M., Escamilla, Christine O., Liu, Shunan, Powell, Craig M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Society for Neuroscience 2020
Materias:	Research Article: New Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294460/ https://www.ncbi.nlm.nih.gov/pubmed/32327468 http://dx.doi.org/10.1523/ENEURO.0332-19.2020

Ejemplares similares

Apparent Genetic Rescue of Adult Shank3 Exon 21 Insertion Mutation Mice Tempered by Appropriate Control Experiments
por: Speed, Haley E., et al.
Publicado: (2019)

Unexpected Compensatory Increase in Shank3 Transcripts in Shank3 Knock-Out Mice Having Partial Deletions of Exons
por: Jin, Chunmei, et al.
Publicado: (2019)

The Shank3(Venus/Venus) knock in mouse enables isoform-specific functional studies of Shank3a
por: Bouquier, Nathalie, et al.
Publicado: (2022)

Phenotypic and functional analysis of SHANK3 stop mutations identified in individuals with ASD and/or ID
por: Cochoy, Daniela M, et al.
Publicado: (2015)

The Neomycin Resistance Cassette in the Targeted Allele of Shank3B Knock-Out Mice Has Potential Off-Target Effects to Produce an Unusual Shank3 Isoform
por: Jin, Chunmei, et al.
Publicado: (2021)

Restoring Shank3 in the rostral brainstem of shank3ab−/− zebrafish autism models rescues sensory deficits
por: Kozol, Robert A., et al.
Publicado: (2021)

Transcriptional and functional complexity of Shank3 provides a molecular framework to understand the phenotypic heterogeneity of SHANK3 causing autism and Shank3 mutant mice
por: Wang, Xiaoming, et al.
Publicado: (2014)

Shank Proteins Differentially Regulate Synaptic Transmission
por: Shi, Rebecca, et al.
Publicado: (2017)

Adult Restoration of Shank3 Expression Rescues Selective Autistic-Like Phenotypes
por: Mei, Yuan, et al.
Publicado: (2016)

CaMKII Phosphorylation Regulates Synaptic Enrichment of Shank3
por: Jeong, Jaehoon, et al.
Publicado: (2021)

An autism-linked missense mutation in SHANK3 reveals the modularity of Shank3 function
por: Wang, Li, et al.
Publicado: (2019)

Pharmacological enhancement of mGlu5 receptors rescues behavioral deficits in SHANK3 knock-out mice
por: Vicidomini, Cinzia, et al.
Publicado: (2016)

Developmental profiling of ASD-related shank3 transcripts and their differential regulation by valproic acid in zebrafish
por: Liu, Chun-xue, et al.
Publicado: (2016)

Immune activation during pregnancy exacerbates ASD-related alterations in Shank3-deficient mice
por: Atanasova, Ekaterina, et al.
Publicado: (2023)

Elevation of SHANK3 Levels by Antisense Oligonucleotides Directed Against the 3′-UTR of the Human SHANK3 mRNA
por: Stirmlinger, Nadine, et al.
Publicado: (2023)

Differentially altered social dominance- and cooperative-like behaviors in Shank2- and Shank3-mutant mice
por: Han, Kyung Ah, et al.
Publicado: (2020)

Intestinal dysmotility in a zebrafish (Danio rerio) shank3a;shank3b mutant model of autism
por: James, David M., et al.
Publicado: (2019)

William Frederick Shanks
Publicado: (1926)

Shank3 influences mammalian sleep development
por: Medina, Elizabeth, et al.
Publicado: (2022)

Dysfunction of Cortical GABAergic Neurons Leads to Sensory Hyper-reactivity in a Shank3 Mouse Model of ASD
por: Chen, Qian, et al.
Publicado: (2020)

Integrative Analysis of Brain Region-specific Shank3 Interactomes for Understanding the Heterogeneity of Neuronal Pathophysiology Related to SHANK3 Mutations
por: Lee, Yeunkum, et al.
Publicado: (2017)

Defective Synapse Maturation and Enhanced Synaptic Plasticity in Shank2 Δex7(–/–) Mice
por: Wegener, Stephanie, et al.
Publicado: (2018)

Distinct Phenotypes of Shank2 Mouse Models Reflect Neuropsychiatric Spectrum Disorders of Human Patients With SHANK2 Variants
por: Eltokhi, Ahmed, et al.
Publicado: (2018)

Striatal Transcriptome and Interactome Analysis of Shank3-overexpressing Mice Reveals the Connectivity between Shank3 and mTORC1 Signaling
por: Lee, Yeunkum, et al.
Publicado: (2017)

Juvenile Shank3 KO Mice Adopt Distinct Hunting Strategies during Prey Capture Learning
por: Groves Kuhnle, Chelsea, et al.
Publicado: (2022)

SHANK3 Genotype Mediates Speech and Language Phenotypes in a Nonclinical Population
por: Manning, Christina, et al.
Publicado: (2021)

The emerging roles of Shank3 in cardiac function and dysfunction
por: Kim, Yoonhee, et al.
Publicado: (2023)

Pull-off characteristics of double-shanked compared to single-shanked ligation clips: an animal study
por: Schenk, Martin, et al.
Publicado: (2016)

Lack of Association between NLGN3, NLGN4, SHANK2 and SHANK3 Gene Variants and Autism Spectrum Disorder in a Chinese Population
por: Liu, Yanyan, et al.
Publicado: (2013)

Evidence that modifier loci have no effect on phenotypic severity in SHANK3-linked autism
Publicado: (2014)

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications
por: Delling, Jan Philipp, et al.
Publicado: (2021)

Zinc Stabilizes Shank3 at the Postsynaptic Density of Hippocampal Synapses
por: Tao-Cheng, Jung-Hwa, et al.
Publicado: (2016)

SHANK3 controls maturation of social reward circuits in the VTA
por: Bariselli, Sebastiano, et al.
Publicado: (2016)

Enhanced Glutamatergic Currents at Birth in Shank3 KO Mice
por: Chiesa, Morgane, et al.
Publicado: (2019)

Shank3 modulates sleep and expression of circadian transcription factors
por: Ingiosi, Ashley M, et al.
Publicado: (2019)

Altered Light Sensitivity of Circadian Clock in Shank3(+/–) Mouse
por: Alamilla, Javier, et al.
Publicado: (2021)

Rare SHANK2 variants in schizophrenia
por: Peykov, S, et al.
Publicado: (2015)

Sex Hormones Regulate SHANK Expression
por: Berkel, Simone, et al.
Publicado: (2018)

Single-molecule fluorescence in-situ hybridization reveals that human SHANK3 mRNA expression varies during development and in autism-associated SHANK3 heterozygosity
por: Taylor, Samuel E., et al.
Publicado: (2018)

Identification of a novel Shank2 transcriptional variant in Shank2 knockout mouse model of autism spectrum disorder
por: Lee, Yong-Seok, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_f8qjgqoov42vi2co688lmq1954