The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis

BACKGROUND: Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. METHODS: The expression levels of 20 cytokines associated with AE infe...

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Autores principales: Ma, Xiao, Zhang, Xuefei, Liu, Jia, Liu, Yufang, Zhao, Cunzhe, Cai, Huixia, Lei, Wen, Ma, Junying, Fan, Haining, Zhou, Jianye, Liu, Na, Zhang, Jingxiao, Wang, Yongshun, Wang, Wei, Zhan, Peizhen, Zhang, Xiongying, Zhang, Qing, Shi, Kemei, Liu, Peiyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294603/
https://www.ncbi.nlm.nih.gov/pubmed/32539714
http://dx.doi.org/10.1186/s12879-020-05135-y
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author Ma, Xiao
Zhang, Xuefei
Liu, Jia
Liu, Yufang
Zhao, Cunzhe
Cai, Huixia
Lei, Wen
Ma, Junying
Fan, Haining
Zhou, Jianye
Liu, Na
Zhang, Jingxiao
Wang, Yongshun
Wang, Wei
Zhan, Peizhen
Zhang, Xiongying
Zhang, Qing
Shi, Kemei
Liu, Peiyun
author_facet Ma, Xiao
Zhang, Xuefei
Liu, Jia
Liu, Yufang
Zhao, Cunzhe
Cai, Huixia
Lei, Wen
Ma, Junying
Fan, Haining
Zhou, Jianye
Liu, Na
Zhang, Jingxiao
Wang, Yongshun
Wang, Wei
Zhan, Peizhen
Zhang, Xiongying
Zhang, Qing
Shi, Kemei
Liu, Peiyun
author_sort Ma, Xiao
collection PubMed
description BACKGROUND: Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. METHODS: The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language. RESULTS: Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group. CONCLUSIONS: The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals.
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spelling pubmed-72946032020-06-16 The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis Ma, Xiao Zhang, Xuefei Liu, Jia Liu, Yufang Zhao, Cunzhe Cai, Huixia Lei, Wen Ma, Junying Fan, Haining Zhou, Jianye Liu, Na Zhang, Jingxiao Wang, Yongshun Wang, Wei Zhan, Peizhen Zhang, Xiongying Zhang, Qing Shi, Kemei Liu, Peiyun BMC Infect Dis Research Article BACKGROUND: Alveolar echinococcosis (AE) is a zoonotic parasitic disease caused by Echinococcus multilocularis larval tapeworm infections in humans that severely impairs the health of affected patients in the northern hemisphere. METHODS: The expression levels of 20 cytokines associated with AE infection were measured by enzyme-linked immunosorbent assay, and the correlations between these cytokines were analysed in the R programming language. RESULTS: Serum cytokine levels differed among individuals in both the AE patient and healthy control groups. The results of the correlations among the cytokines showed obvious differences between the two groups. In the AE patients group, Th1 and Th2 cytokines formed a more complicated network than that in the healthy control group. CONCLUSIONS: The altered correlations between Th1 and Th2 cytokines may be closely associated with AE infection, which may provide a new explanation for the essential differences between AE patients and healthy individuals. BioMed Central 2020-06-15 /pmc/articles/PMC7294603/ /pubmed/32539714 http://dx.doi.org/10.1186/s12879-020-05135-y Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Ma, Xiao
Zhang, Xuefei
Liu, Jia
Liu, Yufang
Zhao, Cunzhe
Cai, Huixia
Lei, Wen
Ma, Junying
Fan, Haining
Zhou, Jianye
Liu, Na
Zhang, Jingxiao
Wang, Yongshun
Wang, Wei
Zhan, Peizhen
Zhang, Xiongying
Zhang, Qing
Shi, Kemei
Liu, Peiyun
The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title_full The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title_fullStr The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title_full_unstemmed The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title_short The correlations between Th1 and Th2 cytokines in human alveolar echinococcosis
title_sort correlations between th1 and th2 cytokines in human alveolar echinococcosis
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294603/
https://www.ncbi.nlm.nih.gov/pubmed/32539714
http://dx.doi.org/10.1186/s12879-020-05135-y
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