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PHGDH supports liver ceramide synthesis and sustains lipid homeostasis

BACKGROUND: d-3-phosphoglycerate dehydrogenase (PHGDH), which encodes the first enzyme in serine biosynthesis, is overexpressed in human cancers and has been proposed as a drug target. However, whether PHGDH is critical for the proliferation or homeostasis of tissues following the postnatal period i...

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Detalles Bibliográficos
Autores principales:	Kang, Yun Pyo, Falzone, Aimee, Liu, Min, González-Sánchez, Paloma, Choi, Bo-Hyun, Coloff, Jonathan L., Saller, James J., Karreth, Florian A., DeNicola, Gina M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2020
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294658/ https://www.ncbi.nlm.nih.gov/pubmed/32549981 http://dx.doi.org/10.1186/s40170-020-00212-x

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