PML2‐mediated thread‐like nuclear bodies mark late senescence in Hutchinson–Gilford progeria syndrome

Progerin accumulation disrupts nuclear lamina integrity and causes nuclear structure abnormalities, leading to premature aging, that is, Hutchinson–Gilford progeria syndrome (HGPS). The roles of nuclear subcompartments, such as PML nuclear bodies (PML NBs), in HGPS pathogenesis, are unclear. Here, w...

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Detalles Bibliográficos
Autores principales: Wang, Ming, Wang, Lulu, Qian, Minxian, Tang, Xiaolong, Liu, Zuojun, Lai, Yiwei, Ao, Ying, Huang, Yinghua, Meng, Yuan, Shi, Lei, Peng, Linyuan, Cao, Xinyue, Wang, Zimei, Qin, Baoming, Liu, Baohua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294779/
https://www.ncbi.nlm.nih.gov/pubmed/32351002
http://dx.doi.org/10.1111/acel.13147

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