SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides

[Image: see text] A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Ad...

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Autores principales: Mahapatra, Subham, Woroch, Cristian P., Butler, Todd W., Carneiro, Sabrina N., Kwan, Sabrina C., Khasnavis, Samuel R., Gu, Junha, Dutra, Jason K., Vetelino, Beth C., Bellenger, Justin, am Ende, Christopher W., Ball, Nicholas D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294807/
https://www.ncbi.nlm.nih.gov/pubmed/32459499
http://dx.doi.org/10.1021/acs.orglett.0c01397
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author Mahapatra, Subham
Woroch, Cristian P.
Butler, Todd W.
Carneiro, Sabrina N.
Kwan, Sabrina C.
Khasnavis, Samuel R.
Gu, Junha
Dutra, Jason K.
Vetelino, Beth C.
Bellenger, Justin
am Ende, Christopher W.
Ball, Nicholas D.
author_facet Mahapatra, Subham
Woroch, Cristian P.
Butler, Todd W.
Carneiro, Sabrina N.
Kwan, Sabrina C.
Khasnavis, Samuel R.
Gu, Junha
Dutra, Jason K.
Vetelino, Beth C.
Bellenger, Justin
am Ende, Christopher W.
Ball, Nicholas D.
author_sort Mahapatra, Subham
collection PubMed
description [Image: see text] A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds.
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spelling pubmed-72948072020-06-16 SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides Mahapatra, Subham Woroch, Cristian P. Butler, Todd W. Carneiro, Sabrina N. Kwan, Sabrina C. Khasnavis, Samuel R. Gu, Junha Dutra, Jason K. Vetelino, Beth C. Bellenger, Justin am Ende, Christopher W. Ball, Nicholas D. Org Lett [Image: see text] A method to activate sulfamoyl fluorides, fluorosulfates, and sulfonyl fluorides with calcium triflimide and DABCO for SuFEx with amines is described. The reaction was applied to a diverse set of sulfamides, sulfamates, and sulfonamides at room temperature under mild conditions. Additionally, we highlight this transformation to parallel medicinal chemistry to generate a broad array of nitrogen-based S(VI) compounds. American Chemical Society 2020-05-27 2020-06-05 /pmc/articles/PMC7294807/ /pubmed/32459499 http://dx.doi.org/10.1021/acs.orglett.0c01397 Text en Copyright © 2020 American Chemical Society This is an open access article published under an ACS AuthorChoice License (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html) , which permits copying and redistribution of the article or any adaptations for non-commercial purposes.
spellingShingle Mahapatra, Subham
Woroch, Cristian P.
Butler, Todd W.
Carneiro, Sabrina N.
Kwan, Sabrina C.
Khasnavis, Samuel R.
Gu, Junha
Dutra, Jason K.
Vetelino, Beth C.
Bellenger, Justin
am Ende, Christopher W.
Ball, Nicholas D.
SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title_full SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title_fullStr SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title_full_unstemmed SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title_short SuFEx Activation with Ca(NTf(2))(2): A Unified Strategy to Access Sulfamides, Sulfamates, and Sulfonamides from S(VI) Fluorides
title_sort sufex activation with ca(ntf(2))(2): a unified strategy to access sulfamides, sulfamates, and sulfonamides from s(vi) fluorides
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294807/
https://www.ncbi.nlm.nih.gov/pubmed/32459499
http://dx.doi.org/10.1021/acs.orglett.0c01397
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