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Discovery of an Allosteric Binding Site in Kinetoplastid Methionyl-tRNA Synthetase

[Image: see text] Methionyl-tRNA synthetase (MetRS) is a chemically validated drug target in kinetoplastid parasites Trypanosoma brucei and Leishmania donovani. To date, all kinetoplastid MetRS inhibitors described bind in a similar way to an expanded methionine pocket and an adjacent, auxiliary poc...

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Detalles Bibliográficos
Autores principales:	Torrie, Leah S., Robinson, David A., Thomas, Michael G., Hobrath, Judith V., Shepherd, Sharon M., Post, John M., Ko, Eun-Jung, Ferreira, Rafael Alves, Mackenzie, Claire J., Wrobel, Karolina, Edwards, Darren P., Gilbert, Ian H., Gray, David W., Fairlamb, Alan H., De Rycker, Manu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2020
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294809/ https://www.ncbi.nlm.nih.gov/pubmed/32275825 http://dx.doi.org/10.1021/acsinfecdis.9b00453

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