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ACE2, Much More Than Just a Receptor for SARS-COV-2

The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potenti...

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Autores principales: Samavati, Lobelia, Uhal, Bruce D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294848/
https://www.ncbi.nlm.nih.gov/pubmed/32582574
http://dx.doi.org/10.3389/fcimb.2020.00317
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author Samavati, Lobelia
Uhal, Bruce D.
author_facet Samavati, Lobelia
Uhal, Bruce D.
author_sort Samavati, Lobelia
collection PubMed
description The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potential target for anti-viral therapeutics. We review the physiological functions of ACE2 in the cardiovascular system and the lungs, and how the activation of ACE2/MAS/G protein coupled receptor contributes in reducing acute injury and inhibiting fibrogenesis of the lungs and protecting the cardiovascular system. In this perspective, we predominantly focus on the impact of SARS-CoV-2 infection on ACE2 and dysregulation of the protective effect of ACE2/MAS/G protein pathway vs. the deleterious effect of Renin/Angiotensin/Aldosterone. We discuss the potential effect of invasion of SARS-CoV-2 on the function of ACE2 and the loss of the protective effect of the ACE2/MAS pathway in alveolar epithelial cells and how this may amplify systemic deleterious effect of renin-angiotensin aldosterone system (RAS) in the host. Furthermore, we speculate the potential of exploiting the modulation of ACE2/MAS pathway as a natural protection of lung injury by modulation of ACE2/MAS axis or by developing targeted drugs to inhibit proteases required for viral entry.
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spelling pubmed-72948482020-06-23 ACE2, Much More Than Just a Receptor for SARS-COV-2 Samavati, Lobelia Uhal, Bruce D. Front Cell Infect Microbiol Cellular and Infection Microbiology The rapidly evolving pandemic of severe acute respiratory syndrome coronavirus (SARS-CoV-2) infection worldwide cost many lives. The angiotensin converting enzyme-2 (ACE-2) has been identified as the receptor for the SARS-CoV-2 viral entry. As such, it is now receiving renewed attention as a potential target for anti-viral therapeutics. We review the physiological functions of ACE2 in the cardiovascular system and the lungs, and how the activation of ACE2/MAS/G protein coupled receptor contributes in reducing acute injury and inhibiting fibrogenesis of the lungs and protecting the cardiovascular system. In this perspective, we predominantly focus on the impact of SARS-CoV-2 infection on ACE2 and dysregulation of the protective effect of ACE2/MAS/G protein pathway vs. the deleterious effect of Renin/Angiotensin/Aldosterone. We discuss the potential effect of invasion of SARS-CoV-2 on the function of ACE2 and the loss of the protective effect of the ACE2/MAS pathway in alveolar epithelial cells and how this may amplify systemic deleterious effect of renin-angiotensin aldosterone system (RAS) in the host. Furthermore, we speculate the potential of exploiting the modulation of ACE2/MAS pathway as a natural protection of lung injury by modulation of ACE2/MAS axis or by developing targeted drugs to inhibit proteases required for viral entry. Frontiers Media S.A. 2020-06-05 /pmc/articles/PMC7294848/ /pubmed/32582574 http://dx.doi.org/10.3389/fcimb.2020.00317 Text en Copyright © 2020 Samavati and Uhal. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Samavati, Lobelia
Uhal, Bruce D.
ACE2, Much More Than Just a Receptor for SARS-COV-2
title ACE2, Much More Than Just a Receptor for SARS-COV-2
title_full ACE2, Much More Than Just a Receptor for SARS-COV-2
title_fullStr ACE2, Much More Than Just a Receptor for SARS-COV-2
title_full_unstemmed ACE2, Much More Than Just a Receptor for SARS-COV-2
title_short ACE2, Much More Than Just a Receptor for SARS-COV-2
title_sort ace2, much more than just a receptor for sars-cov-2
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294848/
https://www.ncbi.nlm.nih.gov/pubmed/32582574
http://dx.doi.org/10.3389/fcimb.2020.00317
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