Cargando…
Focal Active Colitis Presented With Chronic Diarrhea
There are various etiologies of colonic injury and inflammation. The most commonly described colitides in clinical practice are associated with infection, inflammatory bowel disease, ischemia, radiation and medications. The colonic wall has a limited set of responses to different types of injury; th...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Cureus
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294873/ https://www.ncbi.nlm.nih.gov/pubmed/32550060 http://dx.doi.org/10.7759/cureus.8140 |
_version_ | 1783546557214228480 |
---|---|
author | Mandzhieva, Bayarmaa Taylor, John Zafar, Hammad Rashid, Mamoon Ur Khan, Abu H |
author_facet | Mandzhieva, Bayarmaa Taylor, John Zafar, Hammad Rashid, Mamoon Ur Khan, Abu H |
author_sort | Mandzhieva, Bayarmaa |
collection | PubMed |
description | There are various etiologies of colonic injury and inflammation. The most commonly described colitides in clinical practice are associated with infection, inflammatory bowel disease, ischemia, radiation and medications. The colonic wall has a limited set of responses to different types of injury; therefore, there is overlap between many of these disorders. Focal active colitis is characterized by isolated neutrophilic cryptitis with the background mucosa displaying normal crypt architecture. This inflammatory pattern can be easily unnoticed by pathologists because on low-power examination the mucosa may have almost normal appearance. General practitioners also may not be familiar with this term, underlying etiologies, associated risk factors, course, available therapies and follow up. We present a case of an 82-year-old female with chronic diarrhea and weight loss. She had a negative infectious workup and normal radiology series. She subsequently underwent endoscopic evaluation in lieu of persistent and debilitating symptoms which revealed nonspecific macroscopic findings with pathology noting focal active colitis. She was empirically treated with a 14-day course of Xifaxan and responded well to management with almost complete resolution of her symptoms and no recurrence on six-month follow-up. |
format | Online Article Text |
id | pubmed-7294873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Cureus |
record_format | MEDLINE/PubMed |
spelling | pubmed-72948732020-06-16 Focal Active Colitis Presented With Chronic Diarrhea Mandzhieva, Bayarmaa Taylor, John Zafar, Hammad Rashid, Mamoon Ur Khan, Abu H Cureus Internal Medicine There are various etiologies of colonic injury and inflammation. The most commonly described colitides in clinical practice are associated with infection, inflammatory bowel disease, ischemia, radiation and medications. The colonic wall has a limited set of responses to different types of injury; therefore, there is overlap between many of these disorders. Focal active colitis is characterized by isolated neutrophilic cryptitis with the background mucosa displaying normal crypt architecture. This inflammatory pattern can be easily unnoticed by pathologists because on low-power examination the mucosa may have almost normal appearance. General practitioners also may not be familiar with this term, underlying etiologies, associated risk factors, course, available therapies and follow up. We present a case of an 82-year-old female with chronic diarrhea and weight loss. She had a negative infectious workup and normal radiology series. She subsequently underwent endoscopic evaluation in lieu of persistent and debilitating symptoms which revealed nonspecific macroscopic findings with pathology noting focal active colitis. She was empirically treated with a 14-day course of Xifaxan and responded well to management with almost complete resolution of her symptoms and no recurrence on six-month follow-up. Cureus 2020-05-15 /pmc/articles/PMC7294873/ /pubmed/32550060 http://dx.doi.org/10.7759/cureus.8140 Text en Copyright © 2020, Mandzhieva et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Internal Medicine Mandzhieva, Bayarmaa Taylor, John Zafar, Hammad Rashid, Mamoon Ur Khan, Abu H Focal Active Colitis Presented With Chronic Diarrhea |
title | Focal Active Colitis Presented With Chronic Diarrhea |
title_full | Focal Active Colitis Presented With Chronic Diarrhea |
title_fullStr | Focal Active Colitis Presented With Chronic Diarrhea |
title_full_unstemmed | Focal Active Colitis Presented With Chronic Diarrhea |
title_short | Focal Active Colitis Presented With Chronic Diarrhea |
title_sort | focal active colitis presented with chronic diarrhea |
topic | Internal Medicine |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294873/ https://www.ncbi.nlm.nih.gov/pubmed/32550060 http://dx.doi.org/10.7759/cureus.8140 |
work_keys_str_mv | AT mandzhievabayarmaa focalactivecolitispresentedwithchronicdiarrhea AT taylorjohn focalactivecolitispresentedwithchronicdiarrhea AT zafarhammad focalactivecolitispresentedwithchronicdiarrhea AT rashidmamoonur focalactivecolitispresentedwithchronicdiarrhea AT khanabuh focalactivecolitispresentedwithchronicdiarrhea |