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S1P promotes IL-6 expression in osteoblasts through the PI3K, MEK/ERK and NF-κB signaling pathways

Rheumatoid arthritis (RA) is a systemic autoimmune inflammatory disease, in which the immune system attacks joint tissue. Interleukin (IL)-6 is a key proinflammatory cytokine in RA progression. Sphingosine-1-phosphate (S1P), a platelet-derived lysophospholipid mediator, reportedly regulates osteoimm...

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Detalles Bibliográficos
Autores principales:	Hu, Sung-Lin, Huang, Chien-Chung, Tzeng, Tzu-Ting, Liu, Shan-Chi, Tsai, Chun-Hao, Fong, Yi-Chin, Tang, Chih-Hsin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Ivyspring International Publisher 2020
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294913/ https://www.ncbi.nlm.nih.gov/pubmed/32547316 http://dx.doi.org/10.7150/ijms.44612

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