PAK4 phosphorylating RUNX1 promotes ERα-positive breast cancer-induced osteolytic bone destruction

The biological function of nuclear PAK4 in ERα-positive breast cancer osteolytic bone destruction remains unclear. Here, we find that the nuclear PAK4 promotes osteoclastogenesis and tumor-induced osteolysis via phosphorylating RUNX1. We show that nuclear PAK4 interacts with and phosphorylates RUNX1...

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Detalles Bibliográficos
Autores principales: Tang, Lina, Gao, Yunling, Song, Yongqi, Li, Yang, Li, Yanshu, Zhang, Hongyan, Li, Danni, Li, Jiabin, Liu, Caigang, Li, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294946/
https://www.ncbi.nlm.nih.gov/pubmed/32549768
http://dx.doi.org/10.7150/ijbs.47225

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