RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation

DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8...

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Detalles Bibliográficos
Autores principales: Ren, Ling, Zhou, Tingting, Wang, Yang, Wu, Yanmei, Xu, Hongde, Liu, Jingwei, Dong, Xiang, Yi, Fei, Guo, Qiqiang, Wang, Zhuo, Li, Xiaoman, Bai, Ning, Guo, Wendong, Guo, Min, Jiang, Bo, Wu, Xuan, Feng, Yanling, Song, Xiaoyu, Zhang, Siyi, Zhao, Yue, Cao, Liu, Han, Shuai, Xing, Chengzhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294952/
https://www.ncbi.nlm.nih.gov/pubmed/32549753
http://dx.doi.org/10.7150/ijbs.44119
Descripción
Sumario:DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that of c-Myc in colon cancer, which were closely associated with poor survival of colon cancer patients. Furthermore, overexpressing and knocking down RNF8 increased and decreased the expression of c-Myc in colon cancer cells, respectively. In addition, RNF8 interacted with β-catenin and facilitated its nuclear translocation by conjugating K63 polyubiquitination on it. These observations suggested a de novo role of RNF8 in promoting the progression of colon cancer by inducing β-catenin-mediated c-Myc expression.

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