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RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation
DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Ivyspring International Publisher
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294952/ https://www.ncbi.nlm.nih.gov/pubmed/32549753 http://dx.doi.org/10.7150/ijbs.44119 |
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| author | Ren, Ling Zhou, Tingting Wang, Yang Wu, Yanmei Xu, Hongde Liu, Jingwei Dong, Xiang Yi, Fei Guo, Qiqiang Wang, Zhuo Li, Xiaoman Bai, Ning Guo, Wendong Guo, Min Jiang, Bo Wu, Xuan Feng, Yanling Song, Xiaoyu Zhang, Siyi Zhao, Yue Cao, Liu Han, Shuai Xing, Chengzhong |
| author_facet | Ren, Ling Zhou, Tingting Wang, Yang Wu, Yanmei Xu, Hongde Liu, Jingwei Dong, Xiang Yi, Fei Guo, Qiqiang Wang, Zhuo Li, Xiaoman Bai, Ning Guo, Wendong Guo, Min Jiang, Bo Wu, Xuan Feng, Yanling Song, Xiaoyu Zhang, Siyi Zhao, Yue Cao, Liu Han, Shuai Xing, Chengzhong |
| author_sort | Ren, Ling |
| collection | PubMed |
| description | DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that of c-Myc in colon cancer, which were closely associated with poor survival of colon cancer patients. Furthermore, overexpressing and knocking down RNF8 increased and decreased the expression of c-Myc in colon cancer cells, respectively. In addition, RNF8 interacted with β-catenin and facilitated its nuclear translocation by conjugating K63 polyubiquitination on it. These observations suggested a de novo role of RNF8 in promoting the progression of colon cancer by inducing β-catenin-mediated c-Myc expression. |
| format | Online Article Text |
| id | pubmed-7294952 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Ivyspring International Publisher |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-72949522020-06-16 RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation Ren, Ling Zhou, Tingting Wang, Yang Wu, Yanmei Xu, Hongde Liu, Jingwei Dong, Xiang Yi, Fei Guo, Qiqiang Wang, Zhuo Li, Xiaoman Bai, Ning Guo, Wendong Guo, Min Jiang, Bo Wu, Xuan Feng, Yanling Song, Xiaoyu Zhang, Siyi Zhao, Yue Cao, Liu Han, Shuai Xing, Chengzhong Int J Biol Sci Research Paper DNA damage signals transducer RING finger protein 8 (RNF8) is involved in maintaining genomic stability by facilitating the repair of DNA double-strand breaks (DSB) via ubiquitin signaling. By analyzing the TCGA database and colon cancer tissue microarrays, we found that the expression level of RNF8 was positively correlated with that of c-Myc in colon cancer, which were closely associated with poor survival of colon cancer patients. Furthermore, overexpressing and knocking down RNF8 increased and decreased the expression of c-Myc in colon cancer cells, respectively. In addition, RNF8 interacted with β-catenin and facilitated its nuclear translocation by conjugating K63 polyubiquitination on it. These observations suggested a de novo role of RNF8 in promoting the progression of colon cancer by inducing β-catenin-mediated c-Myc expression. Ivyspring International Publisher 2020-05-01 /pmc/articles/PMC7294952/ /pubmed/32549753 http://dx.doi.org/10.7150/ijbs.44119 Text en © The author(s) This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions. |
| spellingShingle | Research Paper Ren, Ling Zhou, Tingting Wang, Yang Wu, Yanmei Xu, Hongde Liu, Jingwei Dong, Xiang Yi, Fei Guo, Qiqiang Wang, Zhuo Li, Xiaoman Bai, Ning Guo, Wendong Guo, Min Jiang, Bo Wu, Xuan Feng, Yanling Song, Xiaoyu Zhang, Siyi Zhao, Yue Cao, Liu Han, Shuai Xing, Chengzhong RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title_full | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title_fullStr | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title_full_unstemmed | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title_short | RNF8 induces β-catenin-mediated c-Myc expression and promotes colon cancer proliferation |
| title_sort | rnf8 induces β-catenin-mediated c-myc expression and promotes colon cancer proliferation |
| topic | Research Paper |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7294952/ https://www.ncbi.nlm.nih.gov/pubmed/32549753 http://dx.doi.org/10.7150/ijbs.44119 |
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