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Inferring protein 3D structure from deep mutation scans

We describe an experimental method of three-dimensional (3D) structure determination that exploits the increasing ease of high-throughput mutational scans. Inspired by the success of using natural, evolutionary sequence co-variation to compute protein and RNA folds, we explored whether ‘laboratory’,...

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Detalles Bibliográficos
Autores principales:	Rollins, Nathan J., Brock, Kelly P., Poelwijk, Frank J., Stiffler, Michael A., Gauthier, Nicholas P., Sander, Chris, Marks, Debora S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295002/ https://www.ncbi.nlm.nih.gov/pubmed/31209393 http://dx.doi.org/10.1038/s41588-019-0432-9

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