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Aurora-A/SOX8/FOXK1 signaling axis promotes chemoresistance via suppression of cell senescence and induction of glucose metabolism in ovarian cancer organoids and cells
Rationale: Cisplatin derivatives are first-line chemotherapeutic agents for epithelial ovarian cancer. However, chemoresistance remains a major hurdle for successful therapy and the underlying molecular mechanisms are poorly understood at present. Methods: RNA sequencing of organoids (PDO) establish...
Autores principales: | Sun, Huizhen, Wang, Husheng, Wang, Xue, Aoki, Yoichi, Wang, Xinjing, Yang, Yufei, Cheng, Xi, Wang, Ziliang, Wang, Xipeng |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Ivyspring International Publisher
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295065/ https://www.ncbi.nlm.nih.gov/pubmed/32550913 http://dx.doi.org/10.7150/thno.43811 |
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