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Neurological features of COVID-19 and their treatment: a review
Severe acute respiratory syndrome–correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. Although direct infection of the central nervous system is uncertain or very rare and the para-infectious complications (e.g. inflammatory n...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioExcel Publishing Ltd
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295105/ https://www.ncbi.nlm.nih.gov/pubmed/32587625 http://dx.doi.org/10.7573/dic.2020-5-1 |
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author | Orsucci, Daniele Ienco, Elena Caldarazzo Nocita, Gianpaolo Napolitano, Alessandro Vista, Marco |
author_facet | Orsucci, Daniele Ienco, Elena Caldarazzo Nocita, Gianpaolo Napolitano, Alessandro Vista, Marco |
author_sort | Orsucci, Daniele |
collection | PubMed |
description | Severe acute respiratory syndrome–correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. Although direct infection of the central nervous system is uncertain or very rare and the para-infectious complications (e.g. inflammatory neuropathies) are rare, delirium and septic encephalopathy are common in severely ill patients. Smell dysfunction and headache are very common in mild cases, especially in younger people and females. Muscle pain is common in both mild and severe cases, and in the most compromised patients, it is accompanied by increased creatine kinase levels and by a likely true myopathic damage. Ischemic stroke has been reported as a possible complication of the hypercoagulability associated with severe SARS-Cov-2 infection, but further studies are needed. Most of the neurological manifestations may occur early in the illness. Therefore, during the pandemic period, neurologists need to be involved, alert, and prepared. Neurological practice will not be the same until a vaccine is available. |
format | Online Article Text |
id | pubmed-7295105 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | BioExcel Publishing Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-72951052020-06-24 Neurological features of COVID-19 and their treatment: a review Orsucci, Daniele Ienco, Elena Caldarazzo Nocita, Gianpaolo Napolitano, Alessandro Vista, Marco Drugs Context Review Severe acute respiratory syndrome–correlated new coronavirus (SARS-Cov-2) infection may result in neurological signs and symptoms through different mechanisms. Although direct infection of the central nervous system is uncertain or very rare and the para-infectious complications (e.g. inflammatory neuropathies) are rare, delirium and septic encephalopathy are common in severely ill patients. Smell dysfunction and headache are very common in mild cases, especially in younger people and females. Muscle pain is common in both mild and severe cases, and in the most compromised patients, it is accompanied by increased creatine kinase levels and by a likely true myopathic damage. Ischemic stroke has been reported as a possible complication of the hypercoagulability associated with severe SARS-Cov-2 infection, but further studies are needed. Most of the neurological manifestations may occur early in the illness. Therefore, during the pandemic period, neurologists need to be involved, alert, and prepared. Neurological practice will not be the same until a vaccine is available. BioExcel Publishing Ltd 2020-06-11 /pmc/articles/PMC7295105/ /pubmed/32587625 http://dx.doi.org/10.7573/dic.2020-5-1 Text en Copyright © 2020 Orsucci D, Caldarazzo Ienco E, Nocita G, Napolitano A, Vista M. Published by Drugs in Context under Creative Commons License Deed CC BY NC ND 4.0 which allows anyone to copy, distribute, and transmit the article provided it is properly attributed in the manner specified below. No commercial use without permission. |
spellingShingle | Review Orsucci, Daniele Ienco, Elena Caldarazzo Nocita, Gianpaolo Napolitano, Alessandro Vista, Marco Neurological features of COVID-19 and their treatment: a review |
title | Neurological features of COVID-19 and their treatment: a review |
title_full | Neurological features of COVID-19 and their treatment: a review |
title_fullStr | Neurological features of COVID-19 and their treatment: a review |
title_full_unstemmed | Neurological features of COVID-19 and their treatment: a review |
title_short | Neurological features of COVID-19 and their treatment: a review |
title_sort | neurological features of covid-19 and their treatment: a review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295105/ https://www.ncbi.nlm.nih.gov/pubmed/32587625 http://dx.doi.org/10.7573/dic.2020-5-1 |
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