Characterization and applications of a Crimean-Congo hemorrhagic fever virus nucleoprotein-specific Affimer: Inhibitory effects in viral replication and development of colorimetric diagnostic tests

Crimean-Congo hemorrhagic fever orthonairovirus (CCHFV) is one of the most widespread medically important arboviruses, causing human infections that result in mortality rates of up to 60%. We describe the selection of a high-affinity small protein (Affimer-NP) that binds specifically to the nucleopr...

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Detalles Bibliográficos
Autores principales: Álvarez-Rodríguez, Beatriz, Tiede, Christian, Hoste, Alexis C. R., Surtees, Rebecca A., Trinh, Chi H., Slack, Gillian S., Chamberlain, John, Hewson, Roger, Fresco, Alba, Sastre, Patricia, Tomlinson, Darren C., Millner, Paul A., Edwards, Thomas A., Barr, John N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295242/
https://www.ncbi.nlm.nih.gov/pubmed/32492018
http://dx.doi.org/10.1371/journal.pntd.0008364

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