Cargando…
Transcriptomic stratification of late-onset Alzheimer's cases reveals novel genetic modifiers of disease pathology
Late-Onset Alzheimer’s disease (LOAD) is a common, complex genetic disorder well-known for its heterogeneous pathology. The genetic heterogeneity underlying common, complex diseases poses a major challenge for targeted therapies and the identification of novel disease-associated variants. Case-contr...
Autores principales: | Milind, Nikhil, Preuss, Christoph, Haber, Annat, Ananda, Guruprasad, Mukherjee, Shubhabrata, John, Cai, Shapley, Sarah, Logsdon, Benjamin A., Crane, Paul K., Carter, Gregory W. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295244/ https://www.ncbi.nlm.nih.gov/pubmed/32492070 http://dx.doi.org/10.1371/journal.pgen.1008775 |
Ejemplares similares
-
Transfer learning‐trained convolutional neural networks identify novel MRI biomarkers of Alzheimer's disease progression
por: Li, Yi, et al.
Publicado: (2021) -
Genetic perturbations of disease risk genes in mice capture transcriptomic signatures of late-onset Alzheimer’s disease
por: Pandey, Ravi S., et al.
Publicado: (2019) -
Systematic tissue-specific functional annotation of the human genome highlights immune-related DNA elements for late-onset Alzheimer’s disease
por: Lu, Qiongshi, et al.
Publicado: (2017) -
A novel systems biology approach to evaluate mouse models of late-onset Alzheimer’s disease
por: Preuss, Christoph, et al.
Publicado: (2020) -
Alzheimer’s Disease: Analyzing the Missing Heritability
por: Ridge, Perry G., et al.
Publicado: (2013)