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Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report

Patient: Male, 73-year-old Final Diagnosis: Ischemic stroke and disseminated tuberculosis Symptoms: Aphasia • deterioration of the level of consciousness • deviation of the labial commissure Medication: — Clinical Procedure: — Specialty: Critical Care Medicine OBJECTIVE: Unusual clinical course BACK...

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Autores principales: Briones-Claudett, Killen H., Briones-Claudett, Mónica H., Briones Zamora, Killen H., Nieves Velez, Rubén D., Martinez Alvarez, Marlon E., Andrade, Michelle Grunauer
Formato: Online Artículo Texto
Lenguaje:English
Publicado: International Scientific Literature, Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295316/
https://www.ncbi.nlm.nih.gov/pubmed/32499476
http://dx.doi.org/10.12659/AJCR.920410
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author Briones-Claudett, Killen H.
Briones-Claudett, Mónica H.
Briones Zamora, Killen H.
Nieves Velez, Rubén D.
Martinez Alvarez, Marlon E.
Andrade, Michelle Grunauer
author_facet Briones-Claudett, Killen H.
Briones-Claudett, Mónica H.
Briones Zamora, Killen H.
Nieves Velez, Rubén D.
Martinez Alvarez, Marlon E.
Andrade, Michelle Grunauer
author_sort Briones-Claudett, Killen H.
collection PubMed
description Patient: Male, 73-year-old Final Diagnosis: Ischemic stroke and disseminated tuberculosis Symptoms: Aphasia • deterioration of the level of consciousness • deviation of the labial commissure Medication: — Clinical Procedure: — Specialty: Critical Care Medicine OBJECTIVE: Unusual clinical course BACKGROUND: Tuberculosis (TB) continues to be a major public health problem worldwide. Extrapulmonary tuberculosis at the level of the central nervous system is the most devastating and deadly form of tuberculosis. CASE REPORT: We present the case of a 73-year-old male Ecuadorian patient with no history of contact with tuberculosis and with a clinical picture of 4 days of evolution characterized by aphasia, deviation of the labial commissure, and deterioration of the level of consciousness with a Glasgow coma score of 7/15. A brain tomography showed evidence of indirect signs of cerebral ischemia; the patient was therefore diagnosed with non-specific cerebrovascular disease. Due to the critical nature of his clinical picture, the patient entered the Intensive Care Unit (ICU), where a chest x-ray was performed and bilateral perihilar alveolar opacities with a reticular and nodular pattern were visualized. These results, combined with the bronchoalveolar brushing, evidenced the presence of Mycobacterium tuberculosis. Adenosine of deaminase (ADA) was also detected in the cerebrospinal fluid with 30.7 µ/L and a molecular biology technique was used with high-multiplex real-time polymerase matrix MALDI-TOF mass spectrometry (Brucker Daltonics) for rapid identification of the causative agent. DNA/polymerase chain reaction (PCR) analyses were used for detection of M. tuberculosis, subsequently confirming the presence of cerebral tuberculosis. CONCLUSIONS: This case illustrated an infrequent form of disseminated tuberculosis in a critically ill patient. Timely diagnosis and appropriate management are essential to reducing mortality.
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spelling pubmed-72953162020-06-22 Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report Briones-Claudett, Killen H. Briones-Claudett, Mónica H. Briones Zamora, Killen H. Nieves Velez, Rubén D. Martinez Alvarez, Marlon E. Andrade, Michelle Grunauer Am J Case Rep Articles Patient: Male, 73-year-old Final Diagnosis: Ischemic stroke and disseminated tuberculosis Symptoms: Aphasia • deterioration of the level of consciousness • deviation of the labial commissure Medication: — Clinical Procedure: — Specialty: Critical Care Medicine OBJECTIVE: Unusual clinical course BACKGROUND: Tuberculosis (TB) continues to be a major public health problem worldwide. Extrapulmonary tuberculosis at the level of the central nervous system is the most devastating and deadly form of tuberculosis. CASE REPORT: We present the case of a 73-year-old male Ecuadorian patient with no history of contact with tuberculosis and with a clinical picture of 4 days of evolution characterized by aphasia, deviation of the labial commissure, and deterioration of the level of consciousness with a Glasgow coma score of 7/15. A brain tomography showed evidence of indirect signs of cerebral ischemia; the patient was therefore diagnosed with non-specific cerebrovascular disease. Due to the critical nature of his clinical picture, the patient entered the Intensive Care Unit (ICU), where a chest x-ray was performed and bilateral perihilar alveolar opacities with a reticular and nodular pattern were visualized. These results, combined with the bronchoalveolar brushing, evidenced the presence of Mycobacterium tuberculosis. Adenosine of deaminase (ADA) was also detected in the cerebrospinal fluid with 30.7 µ/L and a molecular biology technique was used with high-multiplex real-time polymerase matrix MALDI-TOF mass spectrometry (Brucker Daltonics) for rapid identification of the causative agent. DNA/polymerase chain reaction (PCR) analyses were used for detection of M. tuberculosis, subsequently confirming the presence of cerebral tuberculosis. CONCLUSIONS: This case illustrated an infrequent form of disseminated tuberculosis in a critically ill patient. Timely diagnosis and appropriate management are essential to reducing mortality. International Scientific Literature, Inc. 2020-06-05 /pmc/articles/PMC7295316/ /pubmed/32499476 http://dx.doi.org/10.12659/AJCR.920410 Text en © Am J Case Rep, 2020 This work is licensed under Creative Common Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0 (https://creativecommons.org/licenses/by-nc-nd/4.0/) )
spellingShingle Articles
Briones-Claudett, Killen H.
Briones-Claudett, Mónica H.
Briones Zamora, Killen H.
Nieves Velez, Rubén D.
Martinez Alvarez, Marlon E.
Andrade, Michelle Grunauer
Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title_full Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title_fullStr Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title_full_unstemmed Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title_short Ischemic Stroke and Disseminated Tuberculosis in Intensive Care: A Case Report
title_sort ischemic stroke and disseminated tuberculosis in intensive care: a case report
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295316/
https://www.ncbi.nlm.nih.gov/pubmed/32499476
http://dx.doi.org/10.12659/AJCR.920410
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