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HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression

BACKGROUND: The advent of immune checkpoint blockade antibodies has demonstrated that effective mobilization of T cell responses can cause tumor regression of metastatic cancers, although these responses are heterogeneous and restricted to certain histologic types of cancer. To enhance these respons...

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Detalles Bibliográficos
Autores principales:	Chen, Alan Chen, Xu, Renhuan, Wang, Tao, Wei, Junping, Yang, Xiao-Yi, Liu, Cong-Xiao, Lei, Gangjun, Lyerly, Herbert Kim, Heiland, Teri, Hartman, Zachary Conrad
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group 2020
Materias:	Immune Cell Therapies and Immune Cell Engineering
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295440/ https://www.ncbi.nlm.nih.gov/pubmed/32532838 http://dx.doi.org/10.1136/jitc-2019-000258

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