An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections

The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic even...

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Detalles Bibliográficos
Autores principales: Leon, Kristoffer, Ott, Melanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295464/
https://www.ncbi.nlm.nih.gov/pubmed/32553580
http://dx.doi.org/10.1016/j.semcdb.2020.05.018
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author Leon, Kristoffer
Ott, Melanie
author_facet Leon, Kristoffer
Ott, Melanie
author_sort Leon, Kristoffer
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description The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis.
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spelling pubmed-72954642020-06-16 An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections Leon, Kristoffer Ott, Melanie Semin Cell Dev Biol Review The Nonsense-mediated mRNA Decay (NMD) pathway is an RNA quality control pathway conserved among eukaryotic cells. While historically thought to predominantly recognize transcripts with premature termination codons, it is now known that the NMD pathway plays a variety of roles, from homeostatic events to control of viral pathogens. In this review we highlight the reciprocal interactions between the host NMD pathway and viral pathogens, which have shaped both the host antiviral defense and viral pathogenesis. Elsevier Ltd. 2021-03 2020-06-15 /pmc/articles/PMC7295464/ /pubmed/32553580 http://dx.doi.org/10.1016/j.semcdb.2020.05.018 Text en © 2020 Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Review
Leon, Kristoffer
Ott, Melanie
An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title_full An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title_fullStr An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title_full_unstemmed An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title_short An ‘Arms Race’ between the Nonsense-mediated mRNA Decay Pathway and Viral Infections
title_sort ‘arms race’ between the nonsense-mediated mrna decay pathway and viral infections
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295464/
https://www.ncbi.nlm.nih.gov/pubmed/32553580
http://dx.doi.org/10.1016/j.semcdb.2020.05.018
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