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A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults

Indications of cannabis use are numerous although the indication to relief pain remains a major research interest and clinical application. Studies investigating the effect of herbal cannabis and cannabis-based medicine on neuropathic, non-neuropathic pain, acute pain and experimentally induced pain...

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Detalles Bibliográficos
Autores principales: Haleem, Reham, Wright, Robert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295551/
https://www.ncbi.nlm.nih.gov/pubmed/32587650
http://dx.doi.org/10.14740/jocmr4210
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author Haleem, Reham
Wright, Robert
author_facet Haleem, Reham
Wright, Robert
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description Indications of cannabis use are numerous although the indication to relief pain remains a major research interest and clinical application. Studies investigating the effect of herbal cannabis and cannabis-based medicine on neuropathic, non-neuropathic pain, acute pain and experimentally induced pain were reviewed. A search was performed in PubMed and Cochrane library for articles published in English between January 1, 2000 and May 8, 2020. The search terms used were related to cannabis and pain in adults. We identified 34 studies, of which 30 were randomized controlled clinical trials (RCTs). Varying effects were identified from the RCTs, and as expected more promising effects from non-RCTs. Cannabis-based medications were found most effective as an adjuvant therapy in refractory multiple sclerosis, and weak evidence was found to support the treatment of cancer pain especially in advanced stages. Chronic rheumatic pain showed promising results. Adverse events of cannabis-based treatment were found to be more frequent with tetrahydrocannabinol herbal strains compared to other cannabis-derived products.
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spelling pubmed-72955512020-06-24 A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults Haleem, Reham Wright, Robert J Clin Med Res Review Indications of cannabis use are numerous although the indication to relief pain remains a major research interest and clinical application. Studies investigating the effect of herbal cannabis and cannabis-based medicine on neuropathic, non-neuropathic pain, acute pain and experimentally induced pain were reviewed. A search was performed in PubMed and Cochrane library for articles published in English between January 1, 2000 and May 8, 2020. The search terms used were related to cannabis and pain in adults. We identified 34 studies, of which 30 were randomized controlled clinical trials (RCTs). Varying effects were identified from the RCTs, and as expected more promising effects from non-RCTs. Cannabis-based medications were found most effective as an adjuvant therapy in refractory multiple sclerosis, and weak evidence was found to support the treatment of cancer pain especially in advanced stages. Chronic rheumatic pain showed promising results. Adverse events of cannabis-based treatment were found to be more frequent with tetrahydrocannabinol herbal strains compared to other cannabis-derived products. Elmer Press 2020-06 2020-06-04 /pmc/articles/PMC7295551/ /pubmed/32587650 http://dx.doi.org/10.14740/jocmr4210 Text en Copyright 2020, Haleem et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review
Haleem, Reham
Wright, Robert
A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title_full A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title_fullStr A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title_full_unstemmed A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title_short A Scoping Review on Clinical Trials of Pain Reduction With Cannabis Administration in Adults
title_sort scoping review on clinical trials of pain reduction with cannabis administration in adults
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295551/
https://www.ncbi.nlm.nih.gov/pubmed/32587650
http://dx.doi.org/10.14740/jocmr4210
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