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HIV-1 Vpr induces cell cycle arrest and enhances viral gene expression by depleting CCDC137

The HIV-1 Vpr accessory protein induces ubiquitin/proteasome-dependent degradation of many cellular proteins by recruiting them to a cullin4A-DDB1-DCAF1 complex. In so doing, Vpr enhances HIV-1 gene expression and induces (G2/M) cell cycle arrest. However, the identities of Vpr target proteins throu...

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Detalles Bibliográficos
Autores principales: Zhang, Fengwen, Bieniasz, Paul D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295576/
https://www.ncbi.nlm.nih.gov/pubmed/32538781
http://dx.doi.org/10.7554/eLife.55806