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Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea

BACKGROUND: Since its first detection in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has spread rapidly around the world. Although there have been several studies investigating prognostic factors for severe COVID-19, there ha...

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Autores principales: Jang, Jong Geol, Hur, Jian, Choi, Eun Young, Hong, Kyung Soo, Lee, Wonhwa, Ahn, June Hong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Korean Academy of Medical Sciences 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295599/
https://www.ncbi.nlm.nih.gov/pubmed/32537954
http://dx.doi.org/10.3346/jkms.2020.35.e209
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author Jang, Jong Geol
Hur, Jian
Choi, Eun Young
Hong, Kyung Soo
Lee, Wonhwa
Ahn, June Hong
author_facet Jang, Jong Geol
Hur, Jian
Choi, Eun Young
Hong, Kyung Soo
Lee, Wonhwa
Ahn, June Hong
author_sort Jang, Jong Geol
collection PubMed
description BACKGROUND: Since its first detection in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has spread rapidly around the world. Although there have been several studies investigating prognostic factors for severe COVID-19, there have been no such studies in Korea. METHODS: We performed a retrospective observational study of 110 patients with confirmed COVID-19 hospitalized at a tertiary hospital in Daegu, Korea. Demographic, clinical, laboratory, and outcome data were collected and analyzed. Severe disease was defined as a composite outcome of acute respiratory distress syndrome, intensive care unit care, or death. RESULTS: Diabetes mellitus (odds ratio [OR], 19.15; 95% confidence interval [CI], 1.90–193.42; P = 0.012), body temperature ≥ 37.8°C (OR, 10.91; 95% CI, 1.35–88.36; P = 0.025), peripheral oxygen saturation < 92% (OR, 33.31; 95% CI, 2.45–452.22; P = 0.008), and creatine kinase-MB (CK-MB) > 6.3 (OR, 56.84; 95% CI, 2.64–1,223.78, P = 0.010) at admission were associated with higher risk of severe COVID-19. The likelihood of development of severe COVID-19 increased with an increasing number of prognostic factors. CONCLUSION: In conclusion, we found that diabetes mellitus, body temperature ≥ 37.8°C, peripheral oxygen saturation < 92%, and CK-MB > 6.3 are independent predictors of severe disease in hospitalized COVID-19 patients. Appropriate assessment of prognostic factors and close monitoring to provide the necessary interventions at the appropriate time in high-risk patients may reduce the case fatality rate of COVID-19.
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spelling pubmed-72955992020-06-18 Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea Jang, Jong Geol Hur, Jian Choi, Eun Young Hong, Kyung Soo Lee, Wonhwa Ahn, June Hong J Korean Med Sci Original Article BACKGROUND: Since its first detection in December 2019, coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 infection has spread rapidly around the world. Although there have been several studies investigating prognostic factors for severe COVID-19, there have been no such studies in Korea. METHODS: We performed a retrospective observational study of 110 patients with confirmed COVID-19 hospitalized at a tertiary hospital in Daegu, Korea. Demographic, clinical, laboratory, and outcome data were collected and analyzed. Severe disease was defined as a composite outcome of acute respiratory distress syndrome, intensive care unit care, or death. RESULTS: Diabetes mellitus (odds ratio [OR], 19.15; 95% confidence interval [CI], 1.90–193.42; P = 0.012), body temperature ≥ 37.8°C (OR, 10.91; 95% CI, 1.35–88.36; P = 0.025), peripheral oxygen saturation < 92% (OR, 33.31; 95% CI, 2.45–452.22; P = 0.008), and creatine kinase-MB (CK-MB) > 6.3 (OR, 56.84; 95% CI, 2.64–1,223.78, P = 0.010) at admission were associated with higher risk of severe COVID-19. The likelihood of development of severe COVID-19 increased with an increasing number of prognostic factors. CONCLUSION: In conclusion, we found that diabetes mellitus, body temperature ≥ 37.8°C, peripheral oxygen saturation < 92%, and CK-MB > 6.3 are independent predictors of severe disease in hospitalized COVID-19 patients. Appropriate assessment of prognostic factors and close monitoring to provide the necessary interventions at the appropriate time in high-risk patients may reduce the case fatality rate of COVID-19. The Korean Academy of Medical Sciences 2020-06-02 /pmc/articles/PMC7295599/ /pubmed/32537954 http://dx.doi.org/10.3346/jkms.2020.35.e209 Text en © 2020 The Korean Academy of Medical Sciences. https://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (https://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Jang, Jong Geol
Hur, Jian
Choi, Eun Young
Hong, Kyung Soo
Lee, Wonhwa
Ahn, June Hong
Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title_full Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title_fullStr Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title_full_unstemmed Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title_short Prognostic Factors for Severe Coronavirus Disease 2019 in Daegu, Korea
title_sort prognostic factors for severe coronavirus disease 2019 in daegu, korea
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295599/
https://www.ncbi.nlm.nih.gov/pubmed/32537954
http://dx.doi.org/10.3346/jkms.2020.35.e209
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