Brd4 inhibition ameliorates Pyocyanin-mediated macrophage dysfunction via transcriptional repression of reactive oxygen and nitrogen free radical pathways

Macrophages play critical roles in the first-line immune defense against airway infections caused by Pseudomonas aeruginosa (PA). The redox-active phenazine-pyocyanin (PCN), as one of the most essential virulence factors, facilities PA-related infection via a wide spectrum of cellular oxidative dama...

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Detalles Bibliográficos
Autores principales: Zhu, Feimei, Xiong, Feng, He, Jinchen, Liu, Keyun, You, Yuanyuan, Xu, Qian, Miao, Junming, Du, Yu, Zhang, Lijuan, Ren, Hongyu, Wang, Xiaoying, Chen, Junli, Li, Jingyu, Chen, Shanze, Liu, Xiaokang, Huang, Ning, Wang, Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295752/
https://www.ncbi.nlm.nih.gov/pubmed/32541671
http://dx.doi.org/10.1038/s41419-020-2672-0

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