The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms

Metallothionein (MT) is a protein with function of heavy metal detoxification. However, studies about how single nucleotide polymorphisms (SNPs) of MT genes influence lead nephropathy are relatively scarce. Therefore, our aim is to investigate the association between blood lead levels and renal biom...

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Autores principales: Yang, Chen-Cheng, Lin, Chia-I, Lee, Su-Shin, Wang, Chao-Ling, Dai, Chia-Yen, Chuang, Hung-Yi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295782/
https://www.ncbi.nlm.nih.gov/pubmed/32541800
http://dx.doi.org/10.1038/s41598-020-66645-y
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author Yang, Chen-Cheng
Lin, Chia-I
Lee, Su-Shin
Wang, Chao-Ling
Dai, Chia-Yen
Chuang, Hung-Yi
author_facet Yang, Chen-Cheng
Lin, Chia-I
Lee, Su-Shin
Wang, Chao-Ling
Dai, Chia-Yen
Chuang, Hung-Yi
author_sort Yang, Chen-Cheng
collection PubMed
description Metallothionein (MT) is a protein with function of heavy metal detoxification. However, studies about how single nucleotide polymorphisms (SNPs) of MT genes influence lead nephropathy are relatively scarce. Therefore, our aim is to investigate the association between blood lead levels and renal biomarkers and to study whether this association is influenced by the combination of MT1A and MT2A SNPs. Blood lead, urinary uric acid (UA), and urinary N-acetyl-beta-d-glucosaminidase (NAG) levels were analyzed from 485 participants. Genotyping were performed on MT1A SNPs (rs11640851 and rs8052394) and MT2A SNPs (rs10636 and rs28366003). The combined MT1A 2A SNPs were divided into 16 groups. Among renal biomarkers, urinary UA was negatively significant associated with the time-weighted index of cumulative blood lead (TWICL), while urinary NAG was positively significant with TWICL. Furthermore, the association between urinary UA and TWICL was significantly modified by group 6 of combined SNPs (MT1A 2 A SNPs combination were AAAGGGAA, ACAGGGAA, and ACGGGGAA). In conclusion, the negative association of urinary UA and TWICL is modified by group 6, which means participants of group 6 are more susceptible to lead nephrotoxicity.
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spelling pubmed-72957822020-06-17 The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms Yang, Chen-Cheng Lin, Chia-I Lee, Su-Shin Wang, Chao-Ling Dai, Chia-Yen Chuang, Hung-Yi Sci Rep Article Metallothionein (MT) is a protein with function of heavy metal detoxification. However, studies about how single nucleotide polymorphisms (SNPs) of MT genes influence lead nephropathy are relatively scarce. Therefore, our aim is to investigate the association between blood lead levels and renal biomarkers and to study whether this association is influenced by the combination of MT1A and MT2A SNPs. Blood lead, urinary uric acid (UA), and urinary N-acetyl-beta-d-glucosaminidase (NAG) levels were analyzed from 485 participants. Genotyping were performed on MT1A SNPs (rs11640851 and rs8052394) and MT2A SNPs (rs10636 and rs28366003). The combined MT1A 2A SNPs were divided into 16 groups. Among renal biomarkers, urinary UA was negatively significant associated with the time-weighted index of cumulative blood lead (TWICL), while urinary NAG was positively significant with TWICL. Furthermore, the association between urinary UA and TWICL was significantly modified by group 6 of combined SNPs (MT1A 2 A SNPs combination were AAAGGGAA, ACAGGGAA, and ACGGGGAA). In conclusion, the negative association of urinary UA and TWICL is modified by group 6, which means participants of group 6 are more susceptible to lead nephrotoxicity. Nature Publishing Group UK 2020-06-15 /pmc/articles/PMC7295782/ /pubmed/32541800 http://dx.doi.org/10.1038/s41598-020-66645-y Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Yang, Chen-Cheng
Lin, Chia-I
Lee, Su-Shin
Wang, Chao-Ling
Dai, Chia-Yen
Chuang, Hung-Yi
The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title_full The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title_fullStr The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title_full_unstemmed The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title_short The association of blood lead levels and renal effects may be modified by genetic combinations of Metallothionein 1A 2A polymorphisms
title_sort association of blood lead levels and renal effects may be modified by genetic combinations of metallothionein 1a 2a polymorphisms
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295782/
https://www.ncbi.nlm.nih.gov/pubmed/32541800
http://dx.doi.org/10.1038/s41598-020-66645-y
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