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BAP1 is a haploinsufficient tumor suppressor linking chronic pancreatitis to pancreatic cancer in mice

Chronic pancreatitis represents a risk factor for the development of pancreatic cancer. We find that heterozygous loss of histone H2A lysine 119 deubiquitinase BAP1 (BRCA1 Associated Protein-1) associates with a history of chronic pancreatitis and occurs in 25% of pancreatic ductal adenocarcinomas a...

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Detalles Bibliográficos
Autores principales:	Perkail, Stephanie, Andricovich, Jaclyn, Kai, Yan, Tzatsos, Alexandros
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295806/ https://www.ncbi.nlm.nih.gov/pubmed/32541668 http://dx.doi.org/10.1038/s41467-020-16589-8

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