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Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors

Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune response, cardiovascular homeostasis, and cell...

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Autores principales: Evangelista, Eric A., Cho, Christi W., Aliwarga, Theresa, Totah, Rheem A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295938/
https://www.ncbi.nlm.nih.gov/pubmed/32581794
http://dx.doi.org/10.3389/fphar.2020.00828
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author Evangelista, Eric A.
Cho, Christi W.
Aliwarga, Theresa
Totah, Rheem A.
author_facet Evangelista, Eric A.
Cho, Christi W.
Aliwarga, Theresa
Totah, Rheem A.
author_sort Evangelista, Eric A.
collection PubMed
description Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune response, cardiovascular homeostasis, and cell growth regulation. Consequently, eicosanoids are implicated in the pathophysiology of various diseases, most notably cancer, where eicosanoid mediated signaling is involved in tumor development, progression, and angiogenesis. Cytochrome P450s (CYPs) are a superfamily of heme monooxygenases generally involved in the clearance of xenobiotics while a subset of isozymes oxidize PUFAs to eicosanoids. Several eicosanoid forming CYPs are overexpressed in tumors, elevating eicosanoid levels and suggesting a key function in tumorigenesis and progression of tumors in the lung, breast, prostate, and kidney. This review summarizes the current understanding of CYPs' involvement in solid tumor etiology and progression providing supporting public data for gene expression from The Cancer Genome Atlas.
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spelling pubmed-72959382020-06-23 Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors Evangelista, Eric A. Cho, Christi W. Aliwarga, Theresa Totah, Rheem A. Front Pharmacol Pharmacology Oxylipins derived from the oxidation of polyunsaturated fatty acids (PUFAs) act as important paracrine and autocrine signaling molecules. A subclass of oxylipins, the eicosanoids, have a broad range of physiological outcomes in inflammation, the immune response, cardiovascular homeostasis, and cell growth regulation. Consequently, eicosanoids are implicated in the pathophysiology of various diseases, most notably cancer, where eicosanoid mediated signaling is involved in tumor development, progression, and angiogenesis. Cytochrome P450s (CYPs) are a superfamily of heme monooxygenases generally involved in the clearance of xenobiotics while a subset of isozymes oxidize PUFAs to eicosanoids. Several eicosanoid forming CYPs are overexpressed in tumors, elevating eicosanoid levels and suggesting a key function in tumorigenesis and progression of tumors in the lung, breast, prostate, and kidney. This review summarizes the current understanding of CYPs' involvement in solid tumor etiology and progression providing supporting public data for gene expression from The Cancer Genome Atlas. Frontiers Media S.A. 2020-06-09 /pmc/articles/PMC7295938/ /pubmed/32581794 http://dx.doi.org/10.3389/fphar.2020.00828 Text en Copyright © 2020 Evangelista, Cho, Aliwarga and Totah http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Pharmacology
Evangelista, Eric A.
Cho, Christi W.
Aliwarga, Theresa
Totah, Rheem A.
Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title_full Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title_fullStr Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title_full_unstemmed Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title_short Expression and Function of Eicosanoid-Producing Cytochrome P450 Enzymes in Solid Tumors
title_sort expression and function of eicosanoid-producing cytochrome p450 enzymes in solid tumors
topic Pharmacology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295938/
https://www.ncbi.nlm.nih.gov/pubmed/32581794
http://dx.doi.org/10.3389/fphar.2020.00828
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