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Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord
Stereotactic radiation treatment can be used to treat spinal cord neoplasms in patients with either unresectable lesions or residual disease after surgical resection. While treatment guidelines have been suggested for epidural lesions, the utility of stereotactic radiation for intradural and intrame...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295942/ https://www.ncbi.nlm.nih.gov/pubmed/32582555 http://dx.doi.org/10.3389/fonc.2020.00907 |
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author | Liu, Elisa K. Silverman, Joshua S. Sulman, Erik P. |
author_facet | Liu, Elisa K. Silverman, Joshua S. Sulman, Erik P. |
author_sort | Liu, Elisa K. |
collection | PubMed |
description | Stereotactic radiation treatment can be used to treat spinal cord neoplasms in patients with either unresectable lesions or residual disease after surgical resection. While treatment guidelines have been suggested for epidural lesions, the utility of stereotactic radiation for intradural and intramedullary malignancies is still debated. Prior reports have suggested that stereotactic radiation approaches can be used for effective tumor control and symptom management. Treatment-related toxicity has been documented in rare subsets of patients, though the incidences of injury are not directly correlated with higher radiation doses. Further studies are needed to assess the factors that influence the risk of radiation-induced myelopathy when treating spinal cord neoplasms with stereotactic radiation, which can include, but may not be limited to, maximum dose, dose-fractionation, irradiated volume, tumor location, histology and treatment history. This review will discuss evidence for current treatment approaches. |
format | Online Article Text |
id | pubmed-7295942 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72959422020-06-23 Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord Liu, Elisa K. Silverman, Joshua S. Sulman, Erik P. Front Oncol Oncology Stereotactic radiation treatment can be used to treat spinal cord neoplasms in patients with either unresectable lesions or residual disease after surgical resection. While treatment guidelines have been suggested for epidural lesions, the utility of stereotactic radiation for intradural and intramedullary malignancies is still debated. Prior reports have suggested that stereotactic radiation approaches can be used for effective tumor control and symptom management. Treatment-related toxicity has been documented in rare subsets of patients, though the incidences of injury are not directly correlated with higher radiation doses. Further studies are needed to assess the factors that influence the risk of radiation-induced myelopathy when treating spinal cord neoplasms with stereotactic radiation, which can include, but may not be limited to, maximum dose, dose-fractionation, irradiated volume, tumor location, histology and treatment history. This review will discuss evidence for current treatment approaches. Frontiers Media S.A. 2020-06-09 /pmc/articles/PMC7295942/ /pubmed/32582555 http://dx.doi.org/10.3389/fonc.2020.00907 Text en Copyright © 2020 Liu, Silverman and Sulman. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Liu, Elisa K. Silverman, Joshua S. Sulman, Erik P. Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title | Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title_full | Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title_fullStr | Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title_full_unstemmed | Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title_short | Stereotactic Radiation for Treating Primary and Metastatic Neoplasms of the Spinal Cord |
title_sort | stereotactic radiation for treating primary and metastatic neoplasms of the spinal cord |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295942/ https://www.ncbi.nlm.nih.gov/pubmed/32582555 http://dx.doi.org/10.3389/fonc.2020.00907 |
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