Characterization of starvation-induced autophagy in cerebellar Purkinje cells of pHluorin-mKate2-human LC3B transgenic mice

We generated a new transgenic mouse model that expresses a pHluorin-mKate2 fluorescent protein fused with human LC3B (PK-LC3 mice) for monitoring autophagy activity in neurons of the central nervous system. Histological analysis revealed fluorescent puncta in neurons of the cerebral cortex, hippocam...

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Detalles Bibliográficos
Autores principales: Oliva Trejo, Juan Alejandro, Tanida, Isei, Suzuki, Chigure, Kakuta, Soichiro, Tada, Norihiro, Uchiyama, Yasuo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295967/
https://www.ncbi.nlm.nih.gov/pubmed/32541814
http://dx.doi.org/10.1038/s41598-020-66370-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7295967/
https://www.ncbi.nlm.nih.gov/pubmed/32541814
http://dx.doi.org/10.1038/s41598-020-66370-6

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