Using Accelerated Molecular Dynamics Simulation to elucidate the effects of the T198F mutation on the molecular flexibility of the West Nile virus envelope protein

The envelope (E) protein is an important target for antibodies in flavivirus. Literature reports that the mutation T198F, located at the domain I-II hinge of the E protein, regulates viral breathing and increases the accessibility of a distal cryptic epitope located on the fusion loop, having a dire...

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Detalles Bibliográficos
Autores principales: Valente, Renan Patrick da Penha, Souza, Rafael Conceição de, de Medeiros Muniz, Gabriela, Ferreira, João Elias Vidueira, de Miranda, Ricardo Morais, e Lima, Anderson Henrique Lima, Vianez Junior, João Lídio da Silva Gonçalves
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296010/
https://www.ncbi.nlm.nih.gov/pubmed/32541675
http://dx.doi.org/10.1038/s41598-020-66344-8

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