Cargando…

Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients

PURPOSE: To evaluate the concordance between the value of the actual maximum voluntary ventilation (MVV) and the estimated value by multiplying the forced expiratory volume in the first second (FEV(1)) and a different value established in the literature. METHODS: A retrospective study was conducted...

Descripción completa

Detalles Bibliográficos
Autores principales: Otto-Yáñez, Matías, Sarmento da Nóbrega, Antônio José, Torres-Castro, Rodrigo, Araújo, Palomma Russelly Saldanha, Carvalho de Farias, Catharinne Angélica, Dornelas De Andrade, Armele de Fátima, Puppo, Homero, Resqueti, Vanessa Regiane, Fregonezi, Guilherme Augusto de Freitas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296050/
https://www.ncbi.nlm.nih.gov/pubmed/32581835
http://dx.doi.org/10.3389/fphys.2020.00537
_version_ 1783546767292235776
author Otto-Yáñez, Matías
Sarmento da Nóbrega, Antônio José
Torres-Castro, Rodrigo
Araújo, Palomma Russelly Saldanha
Carvalho de Farias, Catharinne Angélica
Dornelas De Andrade, Armele de Fátima
Puppo, Homero
Resqueti, Vanessa Regiane
Fregonezi, Guilherme Augusto de Freitas
author_facet Otto-Yáñez, Matías
Sarmento da Nóbrega, Antônio José
Torres-Castro, Rodrigo
Araújo, Palomma Russelly Saldanha
Carvalho de Farias, Catharinne Angélica
Dornelas De Andrade, Armele de Fátima
Puppo, Homero
Resqueti, Vanessa Regiane
Fregonezi, Guilherme Augusto de Freitas
author_sort Otto-Yáñez, Matías
collection PubMed
description PURPOSE: To evaluate the concordance between the value of the actual maximum voluntary ventilation (MVV) and the estimated value by multiplying the forced expiratory volume in the first second (FEV(1)) and a different value established in the literature. METHODS: A retrospective study was conducted with healthy subjects and patients with stable chronic obstructive pulmonary disease (COPD). Five prediction formulas MVV were used for the comparison with the MVV values. Agreement between MVV measured and MVV obtained from five prediction equations were studied. FEV(1) values were used to estimate MVV. Correlation and agreement analysis of the values was performed in two groups using the Pearson test and the Bland–Altman method; these groups were one group with 207 healthy subjects and the second group with 83 patients diagnosed with COPD, respectively. RESULTS: We recruited 207 healthy subjects (105 women, age 47 ± 17 years) and 83 COPD patients (age 66 ± 6 years; 29 GOLD II, 30 GOLD III, and 24 GOLD IV) for the study. All prediction equations presented a significant correlation with the MVV value (from 0.38 to 0.86, p < 0.05) except for the GOLD II subgroup, which had a poor agreement with measured MVV. In healthy subjects, the mean difference of the value of bias (and limits of agreement) varied between -3.9% (-32.8 to 24.9%), and 27% (-1.4 to 55.3%). In COPD patients, the mean difference of value of bias (and limits of agreement) varied between -4.4% (-49.4 to 40.6%), and 26.3% (-18.3 to 70.9%). The results were similar in the subgroup analysis. CONCLUSION: The equations to estimate the value of MVV present a good degree of correlation with the real value of MVV, but they also show a poor concordance. For this reason, we should not use the estimated results as a replacement for the real value of MVV.
format Online
Article
Text
id pubmed-7296050
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-72960502020-06-23 Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients Otto-Yáñez, Matías Sarmento da Nóbrega, Antônio José Torres-Castro, Rodrigo Araújo, Palomma Russelly Saldanha Carvalho de Farias, Catharinne Angélica Dornelas De Andrade, Armele de Fátima Puppo, Homero Resqueti, Vanessa Regiane Fregonezi, Guilherme Augusto de Freitas Front Physiol Physiology PURPOSE: To evaluate the concordance between the value of the actual maximum voluntary ventilation (MVV) and the estimated value by multiplying the forced expiratory volume in the first second (FEV(1)) and a different value established in the literature. METHODS: A retrospective study was conducted with healthy subjects and patients with stable chronic obstructive pulmonary disease (COPD). Five prediction formulas MVV were used for the comparison with the MVV values. Agreement between MVV measured and MVV obtained from five prediction equations were studied. FEV(1) values were used to estimate MVV. Correlation and agreement analysis of the values was performed in two groups using the Pearson test and the Bland–Altman method; these groups were one group with 207 healthy subjects and the second group with 83 patients diagnosed with COPD, respectively. RESULTS: We recruited 207 healthy subjects (105 women, age 47 ± 17 years) and 83 COPD patients (age 66 ± 6 years; 29 GOLD II, 30 GOLD III, and 24 GOLD IV) for the study. All prediction equations presented a significant correlation with the MVV value (from 0.38 to 0.86, p < 0.05) except for the GOLD II subgroup, which had a poor agreement with measured MVV. In healthy subjects, the mean difference of the value of bias (and limits of agreement) varied between -3.9% (-32.8 to 24.9%), and 27% (-1.4 to 55.3%). In COPD patients, the mean difference of value of bias (and limits of agreement) varied between -4.4% (-49.4 to 40.6%), and 26.3% (-18.3 to 70.9%). The results were similar in the subgroup analysis. CONCLUSION: The equations to estimate the value of MVV present a good degree of correlation with the real value of MVV, but they also show a poor concordance. For this reason, we should not use the estimated results as a replacement for the real value of MVV. Frontiers Media S.A. 2020-06-09 /pmc/articles/PMC7296050/ /pubmed/32581835 http://dx.doi.org/10.3389/fphys.2020.00537 Text en Copyright © 2020 Otto-Yáñez, Sarmento da Nóbrega, Torres-Castro, Araújo, Carvalho de Farias, Dornelas De Andrade, Puppo, Resqueti and Fregonezi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Otto-Yáñez, Matías
Sarmento da Nóbrega, Antônio José
Torres-Castro, Rodrigo
Araújo, Palomma Russelly Saldanha
Carvalho de Farias, Catharinne Angélica
Dornelas De Andrade, Armele de Fátima
Puppo, Homero
Resqueti, Vanessa Regiane
Fregonezi, Guilherme Augusto de Freitas
Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title_full Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title_fullStr Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title_full_unstemmed Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title_short Maximal Voluntary Ventilation Should Not Be Estimated From the Forced Expiratory Volume in the First Second in Healthy People and COPD Patients
title_sort maximal voluntary ventilation should not be estimated from the forced expiratory volume in the first second in healthy people and copd patients
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296050/
https://www.ncbi.nlm.nih.gov/pubmed/32581835
http://dx.doi.org/10.3389/fphys.2020.00537
work_keys_str_mv AT ottoyanezmatias maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT sarmentodanobregaantoniojose maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT torrescastrorodrigo maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT araujopalommarussellysaldanha maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT carvalhodefariascatharinneangelica maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT dornelasdeandradearmeledefatima maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT puppohomero maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT resquetivanessaregiane maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients
AT fregoneziguilhermeaugustodefreitas maximalvoluntaryventilationshouldnotbeestimatedfromtheforcedexpiratoryvolumeinthefirstsecondinhealthypeopleandcopdpatients