The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and...

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Autores principales: Ge, Tongxin, Yang, Jiawen, Zhou, Shihui, Wang, Yuchen, Li, Yakui, Tong, Xuemei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Endocrinology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296058/
https://www.ncbi.nlm.nih.gov/pubmed/32582032
http://dx.doi.org/10.3389/fendo.2020.00365
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author Ge, Tongxin
Yang, Jiawen
Zhou, Shihui
Wang, Yuchen
Li, Yakui
Tong, Xuemei
author_facet Ge, Tongxin
Yang, Jiawen
Zhou, Shihui
Wang, Yuchen
Li, Yakui
Tong, Xuemei
author_sort Ge, Tongxin
collection PubMed
description The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.
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spelling pubmed-72960582020-06-23 The Role of the Pentose Phosphate Pathway in Diabetes and Cancer Ge, Tongxin Yang, Jiawen Zhou, Shihui Wang, Yuchen Li, Yakui Tong, Xuemei Front Endocrinol (Lausanne) Endocrinology The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer. Frontiers Media S.A. 2020-06-09 /pmc/articles/PMC7296058/ /pubmed/32582032 http://dx.doi.org/10.3389/fendo.2020.00365 Text en Copyright © 2020 Ge, Yang, Zhou, Wang, Li and Tong. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Ge, Tongxin
Yang, Jiawen
Zhou, Shihui
Wang, Yuchen
Li, Yakui
Tong, Xuemei
The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title_full The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title_fullStr The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title_full_unstemmed The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title_short The Role of the Pentose Phosphate Pathway in Diabetes and Cancer
title_sort role of the pentose phosphate pathway in diabetes and cancer
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296058/
https://www.ncbi.nlm.nih.gov/pubmed/32582032
http://dx.doi.org/10.3389/fendo.2020.00365
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