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Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage
Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation,...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296108/ https://www.ncbi.nlm.nih.gov/pubmed/32582011 http://dx.doi.org/10.3389/fneur.2020.00483 |
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author | Bustelo, Martín Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martín A. Loidl, C. Fabián Gavilanes, Antonio W. Danilo |
author_facet | Bustelo, Martín Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martín A. Loidl, C. Fabián Gavilanes, Antonio W. Danilo |
author_sort | Bustelo, Martín |
collection | PubMed |
description | Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools. |
format | Online Article Text |
id | pubmed-7296108 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-72961082020-06-23 Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage Bustelo, Martín Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martín A. Loidl, C. Fabián Gavilanes, Antonio W. Danilo Front Neurol Neurology Placental and fetal hypoxia caused by perinatal hypoxic-ischemic events are major causes of stillbirth, neonatal morbidity, and long-term neurological sequelae among surviving neonates. Brain hypoxia and associated pathological processes such as excitotoxicity, apoptosis, necrosis, and inflammation, are associated with lasting disruptions in epigenetic control of gene expression contributing to neurological dysfunction. Recent studies have pointed to DNA (de)methylation, histone modifications, and non-coding RNAs as crucial components of hypoxic-ischemic encephalopathy (HIE). The understanding of epigenetic dysregulation in HIE is essential in the development of new clinical interventions for perinatal HIE. Here, we summarize our current understanding of epigenetic mechanisms underlying the molecular pathology of HI brain damage and its clinical implications in terms of new diagnostic, prognostic, and therapeutic tools. Frontiers Media S.A. 2020-06-09 /pmc/articles/PMC7296108/ /pubmed/32582011 http://dx.doi.org/10.3389/fneur.2020.00483 Text en Copyright © 2020 Bustelo, Barkhuizen, van den Hove, Steinbusch, Bruno, Loidl and Gavilanes. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Bustelo, Martín Barkhuizen, Melinda van den Hove, Daniel L. A. Steinbusch, Harry Wilhelm. M. Bruno, Martín A. Loidl, C. Fabián Gavilanes, Antonio W. Danilo Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_full | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_fullStr | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_full_unstemmed | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_short | Clinical Implications of Epigenetic Dysregulation in Perinatal Hypoxic-Ischemic Brain Damage |
title_sort | clinical implications of epigenetic dysregulation in perinatal hypoxic-ischemic brain damage |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296108/ https://www.ncbi.nlm.nih.gov/pubmed/32582011 http://dx.doi.org/10.3389/fneur.2020.00483 |
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