Nocodazole-Induced Expression and Phosphorylation of Anillin and Other Mitotic Proteins Are Decreased in DNA-Dependent Protein Kinase Catalytic Subunit-Deficient Cells and Rescued by Inhibition of the Anaphase-Promoting Complex/Cyclosome with proTAME but Not Apcin

The DNA-dependent protein kinase catalytic subunit (DNA-PKcs) has well-established roles in DNA double-strand break repair, and recently, nonrepair functions have also been reported. To better understand its cellular functions, we deleted DNA-PKcs from HeLa and A549 cells using CRISPR/Cas9. The resu...

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Detalles Bibliográficos
Autores principales: Douglas, Pauline, Ye, Ruiqiong, Radhamani, Suraj, Cobban, Alexander, Jenkins, Nicole P., Bartlett, Edward, Roveredo, Jonathan, Kettenbach, Arminja N., Lees-Miller, Susan P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296215/
https://www.ncbi.nlm.nih.gov/pubmed/32284347
http://dx.doi.org/10.1128/MCB.00191-19

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