Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review

The prognosis of acute myeloid leukemia (AML) remains poor. Among 180 patients, the median age was 53 (14-88) years. The overall 2-year disease free survival (DFS) was 28.6% (+/- 3.4), 47.7% (+/- 6.6%) for ≤ 40, 23.6% (+/- 5.8%) for 41–60 and 11.7% (+/- 4.2%) for ≥61 (p< 0.0001). The overall 2-ye...

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Autores principales: Abuelgasim, Khadega A., Albuhayri, Bandar, Munshi, Rayan, Mugairi, Areej Al, Alahmari, Bader, Gmati, Giamal, Salama, Hind, Alzahrani, Mohsen, Alhejazi, Ayman, Alaskar, Ahmed, Damlaj, Moussab
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296329/
https://www.ncbi.nlm.nih.gov/pubmed/32566477
http://dx.doi.org/10.1016/j.lrr.2020.100206
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author Abuelgasim, Khadega A.
Albuhayri, Bandar
Munshi, Rayan
Mugairi, Areej Al
Alahmari, Bader
Gmati, Giamal
Salama, Hind
Alzahrani, Mohsen
Alhejazi, Ayman
Alaskar, Ahmed
Damlaj, Moussab
author_facet Abuelgasim, Khadega A.
Albuhayri, Bandar
Munshi, Rayan
Mugairi, Areej Al
Alahmari, Bader
Gmati, Giamal
Salama, Hind
Alzahrani, Mohsen
Alhejazi, Ayman
Alaskar, Ahmed
Damlaj, Moussab
author_sort Abuelgasim, Khadega A.
collection PubMed
description The prognosis of acute myeloid leukemia (AML) remains poor. Among 180 patients, the median age was 53 (14-88) years. The overall 2-year disease free survival (DFS) was 28.6% (+/- 3.4), 47.7% (+/- 6.6%) for ≤ 40, 23.6% (+/- 5.8%) for 41–60 and 11.7% (+/- 4.2%) for ≥61 (p< 0.0001). The overall 2-year survival (OS) was 45.3% (+/- 3.8%), 78.6% (+/- 5.5%) for ≤40, 43.5% (+/- 6.9%) for 41–60 and 15.8% (+/- 4.8%) for ≥61 (p< 0.0001). Induction outcome of ≥61 was best in high dose chemotherapy (HDC) group (p < 0.0001). Only those ≤40 had durable DFS and OS. HDC appears to improve the outcome of older AML patients.
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spelling pubmed-72963292020-06-18 Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review Abuelgasim, Khadega A. Albuhayri, Bandar Munshi, Rayan Mugairi, Areej Al Alahmari, Bader Gmati, Giamal Salama, Hind Alzahrani, Mohsen Alhejazi, Ayman Alaskar, Ahmed Damlaj, Moussab Leuk Res Rep Article The prognosis of acute myeloid leukemia (AML) remains poor. Among 180 patients, the median age was 53 (14-88) years. The overall 2-year disease free survival (DFS) was 28.6% (+/- 3.4), 47.7% (+/- 6.6%) for ≤ 40, 23.6% (+/- 5.8%) for 41–60 and 11.7% (+/- 4.2%) for ≥61 (p< 0.0001). The overall 2-year survival (OS) was 45.3% (+/- 3.8%), 78.6% (+/- 5.5%) for ≤40, 43.5% (+/- 6.9%) for 41–60 and 15.8% (+/- 4.8%) for ≥61 (p< 0.0001). Induction outcome of ≥61 was best in high dose chemotherapy (HDC) group (p < 0.0001). Only those ≤40 had durable DFS and OS. HDC appears to improve the outcome of older AML patients. Elsevier 2020-06-09 /pmc/articles/PMC7296329/ /pubmed/32566477 http://dx.doi.org/10.1016/j.lrr.2020.100206 Text en © 2020 The Author(s) http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle Article
Abuelgasim, Khadega A.
Albuhayri, Bandar
Munshi, Rayan
Mugairi, Areej Al
Alahmari, Bader
Gmati, Giamal
Salama, Hind
Alzahrani, Mohsen
Alhejazi, Ayman
Alaskar, Ahmed
Damlaj, Moussab
Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title_full Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title_fullStr Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title_full_unstemmed Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title_short Impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
title_sort impact of age and induction therapy on outcome of 180 adult patients with acute myeloid leukemia; retrospective analysis and literature review
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296329/
https://www.ncbi.nlm.nih.gov/pubmed/32566477
http://dx.doi.org/10.1016/j.lrr.2020.100206
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