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Chromatin Priming Renders T Cell Tolerance-Associated Genes Sensitive to Activation below the Signaling Threshold for Immune Response Genes

Immunological homeostasis in T cells is maintained by a tightly regulated signaling and transcriptional network. Full engagement of effector T cells occurs only when signaling exceeds a critical threshold that enables induction of immune response genes carrying an epigenetic memory of prior activati...

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Detalles Bibliográficos
Autores principales:	Bevington, Sarah L., Ng, Sky T.H., Britton, Graham J., Keane, Peter, Wraith, David C., Cockerill, Peter N.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cell Press 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296351/ https://www.ncbi.nlm.nih.gov/pubmed/32521273 http://dx.doi.org/10.1016/j.celrep.2020.107748

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