Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

Immune evasion is a major obstacle for cancer treatment. Common mechanisms include impaired antigen presentation through mutations or loss of heterozygosity (LOH) of the major histocompatibility complex class I (MHC-I), which has been implicated in resistance to immune checkpoint blockade (ICB) ther...

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Detalles Bibliográficos
Autores principales: Yamamoto, Keisuke, Venida, Anthony, Yano, Julian, Biancur, Douglas E., Kakiuchi, Miwako, Gupta, Suprit, Sohn, Albert S.W., Mukhopadhyay, Subhadip, Lin, Elaine Y., Parker, Seth J., Banh, Robert S., Paulo, Joao A., Wen, Kwun Wah, Debnath, Jayanta, Kim, Grace E., Mancias, Joseph D., Fearon, Douglas T., Perera, Rushika M., Kimmelman, Alec C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7296553/
https://www.ncbi.nlm.nih.gov/pubmed/32376951
http://dx.doi.org/10.1038/s41586-020-2229-5

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